Canonical Wnt signaling has been demonstrated to increase bone formation, and Wnt
pathway components are being pursued as potential drug targets for osteoporosis and other …

A nitrone-based entry into the tropane class of alkaloids is described. Syntheses of
pseudotropine and (//-cocaine are discussed. The synthetic utility and the high degree of …

with 2-methoxypropene16 in CCU in the presence of a trace of phosphorus oxychloride and
exposed to 3 equiv of lithium acetylide-ethylenediamine complex in dimethyl sulfoxide at 25 …

The diphenylsulfonyl sulfonamide scaffold represented by 1 (WAY-316606) are small
molecule inhibitors of the secreted protein sFRP-1, an endogenous antagonist of the secreted …

These results indicated that theadenine ring was constituted from two molecules of formamide
and three molecules of hydrogen cyanide. Among the CN units in adenine, C5-N7, Ce-…

Our efforts in seeking low molecular weight agonists of the antidiuretic peptide hormone
arginine vasopressin (AVP) have led to the identification of the clinical candidate WAY-151932 (…

The discovery of a series of 4-aminoethyl-3-(phenylsulfonyl)-1H-indoles, dual acting
norepinephrine reuptake inhibitors (NRIs) and 5-HT 2A receptor antagonists, is described. The …

Compounds with a combination of norepinephrine and serotonin reuptake inhibition have
been approved in the US and Europe for a number of indications, including major depressive …

The anti-inflammatory activity of non-selective estrogens has been attributed to their ability
to antagonize the activity of nuclear factor κB (NF-κB), a known mediator of inflammatory …

Chemical Proof of Structure of a-Cyanoglycine (5) and a-Cyanoglycine-NCA (4).(a)
Formation of N-Trifluoroacetyl Methyl Ester Derivatives. Methyl aminocyanoacetate-p-toluene …