Simple Summary Pancreatic ductal adenocarcinoma (PDAC) is an aggressive and chemoresistant
cancer, with a poor overall survival. The stiff stroma surrounding PDAC is known to …

Cell migration is essential in a number of processes, including wound healing, angiogenesis
and cancer metastasis. Especially, invasion of cancer cells in the surrounding tissue is a …

We have recently shown that the adaptor protein p140Cap regulates tumor properties in
terms of cell motility and growth. Here, by using the highly metastatic rat adenocarcinoma cell …

Tumour progression involves a series of sequential steps leading to metastasis. For several
of these steps, tumour cells must be equipped with the appropriate adhesive phenotype. …

Purpose Chemoresistance remains a major challenge in treating pancreatic ductal
adenocarcinoma (PDAC). Although chemoradiation has proven effective in other tumor types, such …

PURPOSE: During the process of metastasis, changes in cell-cell and cell-matrix contacts
occur; therefore, expression of integrins, a superfamily of adhesion molecules, may be …

Introduction: PDAC is an extremely aggressive tumor with a poor prognosis and remarkable
therapeutic resistance. The dense extracellular matrix (ECM) which characterizes PDAC …

In cell–matrix adhesions, integrin receptors and associated proteins provide a dynamic
coupling of the extracellular matrix (ECM) to the cytoskeleton. This allows bidirectional …

Cell survival, differentiation, and migration are all dependent on the cell’s interaction with its
external environment. In addition to chemical cues, cells react to their physical environment, …

Pancreatic ductal adenocarcinoma (PDAC) is a highly malignant tumor characterized by
intrinsic or rapidly acquired chemoresistance. The remarkable desmoplastic response has been …