Most biopharmaceutical therapeutics elicit some level of antibody response against the
product. This antibody response can, in some cases, lead to potentially serious side effects and/…

An evaluation of potential antibody formation to biologic therapeutics during the course of
nonclinical safety studies and its impact on the toxicity profile is expected under current …

… collected and structure solved by us; b= data collected by Molecular Structure Corporation
(MSC) and solved by us; c= the complete structure determination was performed by MSC; d= …

… 2.67 A) exist between the fluorines of tape D and the barbital CH3 hydrogens of tape C in
Figure 11, although the disorder … The quantity d + d' is constant at about 10 A, and this value is …

The potential immunogenicity of new protein therapeutics raises concerns about the
possibility of inducing untoward immune reactions in humans. It is generally assumed that all …

Immune-mediated drug hypersensitivity reactions (IDHR) have a significant impact on clinical
practice, drug development, and public health. However, research to understand IDHR …

The development and regulatory approval of immunomodulatory pharmaceuticals to treat
many human diseases has increased significantly over the last two decades. As discussed by …

A1R3+ PhOH— 1/2 [R2Al (M-OPh)] 2(1) of 2 and 3 equiv of phenol yields the di-and trisubstituted
complexes AlR (OPh) 2 and Al (OPh) 3, respectively. 2 Analogous reactions with the …

Two new chiral catalysts, 9 and 14, have been developed for the enantioselective addition
of dialkylzinc reagents to aromatic aldehydes, as exemplified by the re-action of …

Bone marrow stroma consists predominately of two cell types, macrophages and fibroblastoid
stromal cells, which regulate the growth and differentiation of myelopoietic cells via the …