Metabotropic (G-protein-coupled) glutamate (mGlu) receptors have now emerged as a
recognized, but still relatively new area of excitatory amino acid research. Current understanding …

The G protein‐coupled metabotropic glutamate (mGlu) receptors are differentially localized
at various synapses throughout the brain. Depending on the receptor subtype, they appear to …

Metabotropic glutamate receptors (mGluRs) are a novel family of recently cloned G protein-coupled
receptors. These receptors are heterogeneous and coupled to multiple second …

Aggregation of the amyloid-β (Aβ) peptide in the extracellular space of the brain is central to
Alzheimer's disease pathogenesis. Aβ aggregation is concentration dependent and brain …

Schizophrenia is a chronic, complex and heterogeneous mental disorder, with pathological
features of disrupted neuronal excitability and plasticity within limbic structures of the brain. …

Metabotropic glutamate (mGlu) receptors, which include mGlu1–8 receptors, are a heterogeneous
family of G-protein-coupled receptors which function to modulate brain excitability via …

Anxiety and stress disorders are the most commonly occurring of all mental illnesses, and
current treatments are less than satisfactory. So, the discovery of novel approaches to treat …

Metabotropic glutamate (mGlu) receptors were discovered in the mid 1980s and originally
described as glutamate receptors coupled to polyphosphoinositide hydrolysis. Almost 6500 …

2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (9) was designed as a conformationally
constrained analog of glutamic acid. For 9, the key torsion angles (τ 1 and τ 2 ) which …

The in vitro pharmacology of a structurally novel compound, LY341495, was investigated at
human recombinant metabotropic glutamate (mGlu) receptor subtypes expressed in non-…