The recent rate of emergence of pathogenic fungi that are resistant to the limited number of
commonly used antifungal agents is unprecedented. The azoles, for example, are used not …

Candida albicans and related species pathogenic for man become resistant to antifungal
agents, in particular triazole compounds, by expression of efflux pumps that reduce drug …

… Finally, the echinocandins (caspofungin, anidulafungin, and micafungin) are cell wall–active
agents that inhibit the biosynthesis of β-1,3-d-glucan, a major structural component of the …

Azole antifungal agents, and especially fluconazole, have been used widely to treat
oropharyngeal candidiasis in patients with AIDS. An increasing number of cases of clinical …

… Probes specific for the CDR1 andCDR2 genes were prepared as described by Sanglard
and colleagues by PCR amplification from plasmids containing these sequences (18, 32). All …

… Several new genes were isolated, one of which was a new ABC transporter gene called
CDR2 (Candida drug resistance). The protein Cdr2p encoded by this gene exhibited 84% …

… , but without excluding the involvement of other factors (D. Sanglard, K. Kuchler, F. Ischer,
J.-… 4D). A mixture of cut and uncut DNA is observed in alleles amplified from isolate C43, …

… We calculated the doubling times (t d s) to be between 102 and 106 min for strains CAF2-1,
DSY1216, and DSY1336, all of which carry functional ERG11 and ERG3 alleles, and for the …

The resistance mechanisms to azole antifungal agents were investigated in this study with two
pairs of Candida glabrata clinical isolates recovered from two separate AIDS patients. The …

Recent sequencing and assembly of the genome for the fungal pathogen Candida albicans
used simple automated procedures for the identification of putative genes. We have …