Intracellular pH (pH i) has an important role in the maintenance of normal cell function, and
hence this parameter has to be tightly controlled within a narrow range, largely through the …

Obesity is a chronic, relapsing condition characterized by excess body fat. Its prevalence
has increased globally since the 1970s, and the number of obese and overweight people is …

Obesity is a multifactorial disease with both genetic and environmental components. The
prevailing view is that obesity results from an imbalance between energy intake and …

Although TRAIL (tumor necrosis factor (TNF)-related apoptosis inducing ligand) is a well-known
apoptosis inducer, we have previously demonstrated that acidic extracellular pH (pHe) …

We have shown previously that the death receptor CD95 could contribute to anticancer drug-induced
apoptosis of colon cancer cells. In addition, anticancer drugs cooperate with CD95 …

1 Intracellular pH was recorded fluorimetrically by using carboxy‐SNARF‐1, AM‐loaded into
superfused ventricular myocytes isolated from guinea‐pig heart. Intracellular acid and base …

It has been suggested that alterations in intracellular Ca2+ homeostasis may be
responsible for the development of diabetic cardiomyopathy. We have studied the effects of …

… A preliminary account of this work has been published (Lagadic-Gossmann, Buckler & …
NaHCO3 were replaced with 140 mm N-methyl-D-glucamine (NMG) and the pH was adjusted to 7'…

We have previously shown that cisplatin triggers an early acid sphingomyelinase (aSMase)-dependent
ceramide generation concomitantly with an increase in membrane fluidity and …

The human probiotic Propionibacterium freudenreichii kills colorectal adenocarcinoma cells
through apoptosis in vitro via its metabolites, the short chain fatty acids (SCFA), acetate and …