Toxicity of alpidem, a peripheral benzodiazepine receptor ligand, but not zolpidem, in rat hepatocytes: role of mitochondrial permeability transition and metabolic …

A Berson, V Descatoire, A Sutton, D Fau… - … of Pharmacology and …, 2001 - ASPET
Whereas alpidem is hepatotoxic, zolpidem is not. Despite closely related chemical structures,
alpidem, but not zolpidem, is a peripheral benzodiazepine receptor (PBR) ligand, and is …

Hepatotoxicity of the herbal medicine germander: Metabolic activation of its furano diterpenoids by cytochrome P450 3A depletes cytoskeleton–associated protein …

…, D Pessayre, JM Lereau, C Moulis, I Fouraste, D Fau - Hepatology, 1996 - journals.lww.com
… Aerial parts of the plant in bloom were (L’Isle-D’Abeau-Chesnes, France). All solvents were
from Prolabo used … Castot A, Larrey D. Hépatites observées au cours d’un traitement par un …

Cytochrome P450–generated reactive metabolites cause mitochondrial permeability transition, caspase activation, and apoptosis in rat hepatocytes

…, MA Robin, P Lettéron, D Fau, D Pessayre - Hepatology, 2000 - Elsevier
Although cytochrome P-450 (CYP)-generated reactive metabolites can cause hepatocyte
apoptosis, the mechanism of this effect is incompletely understood. In the present study, we …

Toxicity of the antiandrogen flutamide in isolated rat hepatocytes.

D Fau, D Eugene, A Berson, P Letteron… - … of Pharmacology and …, 1994 - ASPET
The hepatotoxicity of flutamide, an antiandrogen that produces hepatitis in some human
recipients, was studied in isolated rat hepatocytes. Flutamide (1 mM) led to the covalent binding …

Mechanism for the hepatotoxicity of the antiandrogen, nilutamide. Evidence suggesting that redox cycling of this nitroaromatic drug leads to oxidative stress in isolated …

D Fau, A Berson, D Eugene, B Fromenty, C Fisch… - … of Pharmacology and …, 1992 - ASPET
The nitroaromatic drug nilutamide has been shown previously to undergo redox cycling in
aerobic rat liver microsomes, being reduced by NADPH-cytochrome P-450 reductase to a …

[PDF][PDF] Opening of the mitochondrial permeability transition pore causes matrix expansion and outer membrane rupture in Fas‐mediated hepatic apoptosis in mice

…, A Berson, A Mansouri, D Fau, D Pessayre - …, 2000 - Wiley Online Library
Although Fas stimulation has been reported to cause outer mitochondrial membrane
rupture in Jurkat cells, the mechanism of this effect is debated, and it is not known if outer …

[PDF][PDF] Diterpenoids from germander, an herbal medicine, induce apoptosis in isolated rat hepatocytes

D Fau, M Lekehal, G Farrell, A Moreau… - …, 1997 - academia.edu
… Pessayre D. Role of reactive metabolites in drug-induced hepatitienilic acid adducts are
transported to the plasma membrane … Berson A, Wolf C, Berger V, Fau D, Chachaty C …

Hepatotoxicity of germander in mice

…, C Moulis, C Degott, P Dansette, D Fau, D Pessayre - Gastroenterology, 1994 - Elsevier
… C:astot A, Larrey D. Hbpatites observees au tours d’un traitement par un medicament ou
une tisane contenant de la Germandrde petitchene. Bilan des 26 cas rapport& aux Centres …

Withdrawal of life support, altruistic suicide, fratricidal killing and euthanasia by lymphocytes: different forms of drug-induced hepatic apoptosis

D Pessayre, D Haouzi, D Fau, MA Robin… - Journal of …, 1999 - journal-of-hepatology.eu
… The latter effects may be mediated through the binding of mitochondrial cyclophilin D to
the … Direct demonstation of a specific interaction between cyclophilin-D and the adenine …

Mechanisms for experimental buprenorphine hepatotoxicity: major role of mitochondrial dysfunction versus metabolic activation

A Berson, D Fau, R Fornacciari, P Degove-Goddard… - Journal of …, 2001 - Elsevier
Background/Aims: Although sublingual buprenorphine is safely used as a substitution drug
in heroin addicts, large overdoses or intravenous misuse may cause hepatitis. …