Research conducted during the past 30 years has increased our understanding of the
mechanisms involved in colorectal cancer initiation and development. The findings have …

… IBS-C patients and higher in IBS-D patients. The results then … 4 d), in the treatment of 85 IBS
patients (randomized IBS-D or … effective in patients affected by IBS-D (P<0.001). Moreover, …

… 7 A–D, which is published as supporting information on the PNAS web site). Because FAD
mutations often alter the Aβ42 EV /Aβ40 EV ratio (1), we first searched for siRNAs with that …

Over half of all antibiotics target the bacterial ribosomenature’s complex, 2.5 MDa
nanomachine responsible for decoding mRNA and synthesizing proteins. Macrolide antibiotics, …

We present the design and a prototype implementation of a three-dimensional visualization
system to assist with laparoscopic surgical procedures. The system uses 3D visualization, …

… The IC 50 values for BACE1, BACE2, renin, and cathepsin D were derived from in vitro
enzymatic assays. Cellular potency was measured in a cell line expressing an APP substrate with …

This article reports results on the effects of hyperbolic nozzle geometry on the local heat-transfer
coefficients for confined impinging air jets. A thermochromatic liquid-crystal technique is …

The serum/plasma protein binding and blood distribution of artemether and lumefantrine
was studied in vitro. The techniques used were the erythrocyte partitioning and ultrafiltration …

… (D) Number of water molecules within 8 Å of Met 165 (gray); the running average of the …
The tert-butyl group in D is not essential, and the cyclobutyl group can be modified to an alkyl or …

A small molecule inhibitor of β-secretase with a unique binding mode has been developed.
Crystallographic determination of the enzyme–inhibitor complex shows the catalytic …