Apoptotic events in a human ovarian cancer cell line exposed to anthracyclines

D Bellarosa, A Ciucci, A Bullo, F Nardelli… - … of Pharmacology and …, 2001 - ASPET
Cytotoxic drugs commonly used in cancer therapy promote tumor cell death by inducing
apoptosis, but the cell death pathway(s) is likely dependent on the mechanism of drug action. In …

[HTML][HTML] CD157: from myeloid cell differentiation marker to therapeutic target in acute myeloid leukemia

…, G Fissolo, S Peola, C Bracci, M Binaschi, D Bellarosa… - Cells, 2019 - mdpi.com
Human CD157/BST-1 and CD38 are dual receptor-enzymes derived by gene duplication
that belong to the ADP ribosyl cyclase gene family. First identified over 30 years ago as Mo5 …

[HTML][HTML] Antitumor activity of the PI3K δ-sparing inhibitor MEN1611 in PIK3CA mutated, trastuzumab-resistant HER2+ breast cancer

…, S Talucci, D Bisignano, A Bressan, D Bellarosa… - Breast Cancer Research …, 2023 - Springer
Purpose Dysregulation of the PI3K pathway is one of the most common events in breast
cancer. Here we investigate the activity of the PI3K inhibitor MEN1611 at both molecular and …

Inhibition of telomerase activity by a distamycin derivative: effects on cell proliferation and induction of apoptosis in human cancer cells

N Zaffaroni, S Lualdi, R Villa, D Bellarosa… - European Journal of …, 2002 - Elsevier
In this study, we evaluated the potential of the distamycin derivative MEN 10716 as a
telomerase inhibitor. Exposure of human melanoma cell extracts to MEN 10716 induced a dose-…

MEN1309/OBT076, a first-in-class antibody–drug conjugate targeting CD205 in solid tumors

…, M Bigioni, A Bressan, C Carrisi, D Bellarosa… - Molecular cancer …, 2019 - AACR
CD205 is a type I transmembrane glycoprotein and is a member of the C-type lectin receptor
family. Analysis by mass spectrometry revealed that CD205 was robustly expressed and …

[HTML][HTML] SAHA/Vorinostat induces the expression of the CD137 receptor/ligand system and enhances apoptosis mediated by soluble CD137 receptor in a human …

D Bellarosa, A Bressan, M Bigioni… - International …, 2012 - spandidos-publications.com
… (5 μg/well) at 25C with 40 μM of Fluor de Lys™ substrate. Reactions were stopped after 30
min with Fluor de Lys™ developer and fluorescence measured using a Victor1420 microplate …

New arylpyrido-diazepine and-thiodiazepine derivatives are potent and highly selective HIV-1 inhibitors targeted at the reverse transcriptase

D Bellarosa, G Antonelli, F Bambacioni, D Giannotti… - Antiviral research, 1996 - Elsevier
A series of pyridobenzothiodiazepindioxides such as the 11-ethyl-6,8,9-trimethyl-6,11-dihydro-pyrido[2,3-f][2,1,5]benzothiodiazepine-5,5-dioxide
and arylpiridodiazepines such as the 6,…

Sabarubicin-(MEN 10755) and paclitaxel show different kinetics in nuclear factor-kappaB (NF-kB) activation: effect of parthenolide on their cytotoxicity

D Bellarosa, M Binaschi, CA Maggi… - Anticancer research, 2005 - ar.iiarjournals.org
Background: Several antitumor drugs have been described to induce nuclear factor kappaB
(NF-Î B), but results about its role in regulating apoptotic cell death are quite controversial. In …

In vitro Selection of Human Immunodeficiency Virus Type 1 Resistant to Ro 31-8959 Proteinase Inhibitor

…, E Riva, G Dong, D Bellarosa - Antiviral Chemistry …, 1993 - journals.sagepub.com
Human immunodeficiency virus type I (HIV-1) resistant to the proteinase inhibitor Ro 31–8959
has been obtained by growing HIV-IIIB in C8166 cell cultures in the presence of inhibitory …

The synergistic interaction of interferon types I and II leads to marked reduction in severe acute respiratory syndrome-associated coronavirus replication and increase …

…, S Trombetti, A Alberelli, S Cicetti, D Bellarosa… - Intervirology, 2007 - karger.com
Interferon (IFN)-α, -β and -γ have been shown to be only marginally effective against severe
acute respiratory syndrome coronavirus (SARS-CoV) replication in Vero cell lines. We …