We investigated the role of Akt-1, one of the major downstream effectors of phosphoinositide
3-kinase (PI3K), in platelet function using mice in which the gene for Akt-1 had been …

Sphingosylphosphorylcholine (SPC) is a bioactive lipid that acts as an intracellular and
extracellular signalling molecule in numerous biological processes. Many of the cellular actions …

Compartmentalization of cAMP-dependent protein kinase A (PKA) by A-kinase anchoring
proteins (AKAPs) targets PKA to distinct subcellular locations in many cell types. However, the …

Background— Antibodies to the β 1 -adrenergic receptor (β 1 AR) are detected in a
substantial number of patients with idiopathic dilated cardiomyopathy (DCM). The mechanism …

Transient receptor potential channels of the ankyrin subtype-1 (TRPA1) and vanilloid
subtype-1 (TRPV1) are structurally related, non-selective cation channels that show a high …

Objective— Endothelial cell (EC) migration, essential for reestablishing arterial integrity
after vascular injury, is inhibited by oxidized LDL (oxLDL) and lysophosphatidylcholine (lysoPC) …

Essential oils were obtained by hydrodistillation of the umbels+seeds and stems of Ferula
akitschkensis (FAEO u/s and FAEO stm , respectively) and analyzed by gas chromatography …

We have previously shown transient receptor potential vanilloid subtype 1 (TRPV1) channel-dependent
coronary function is compromised in pigs with metabolic syndrome (MetS). …

Rationale: Transient receptor potential channels of the ankyrin subtype-1 (TRPA1) are non-selective
cation channels that show high permeability to calcium. Previous studies from our …

Lipid oxidation products, including lysophosphatidylcholine (lysoPC), activate canonical
transient receptor potential 6 (TRPC6) channels leading to inhibition of endothelial cell (EC) …