The G protein-coupled receptor (GPCR) superfamily of integral proteins is the largest family
of signal transducers, comprised of ∼1000 members. Considering their prevalence and …

Pregnenolone is considered the inactive precursor of all steroid hormones, and its potential
functional effects have been largely uninvestigated. The administration of the main active …

Purpose: Although the use of stents after ureteroscopy has been studied extensively,
relatively little has been published about stent placement before complicated ureteroscopic …

Chimeric antigen receptor (CAR) T cell therapy relies on T cells that are guided by synthetic
receptors to target and lyse cancer cells. CARs bind to cell surface antigens through an scFv …

Humans show remarkable ability to adapt their social behavior to suit the changing requirements
of their interactions. An interaction partner's social cues, particularly facial expressions, …

The cannabinoid 1 (CB 1 ) allosteric modulator, 5-chloro-3-ethyl-1H-indole-2-carboxylic
acid [2-(4-piperidin-1-yl-phenyl)-ethyl]-amide) (ORG27569), has the paradoxical effect of …

G protein-coupled receptors (GPCRs) play a key role in many cellular signaling mechanisms,
and must select among multiple coupling possibilities in a ligand-specific manner in order …

We have recently identified 1,8-naphthyridin-2(1H)-one-3-carboxamide as a new scaffold
very suitable for the development of new CB2 receptor potent and selective ligands. In this …

GPR55 is a class AG protein-coupled receptor (GPCR) that has been implicated in inflammatory
pain, neuropathic pain, metabolic disorder, bone development, and cancer. Initially …

Activation of the cannabinoid CB 1 receptor (CB 1 ) is modulated by aspartate residue D2.63
in transmembrane helix (TMH) 2. Interestingly, D2.63 does not affect the affinity for ligand …