Several excellent guidelines already exist on treating patients who have ventricular
arrhythmias (Table 1). The purpose of this document is to update and combine the previously …

The single most common cause of the withdrawal or restriction of the use of marketed drugs
has been QT-interval prolongation associated with polymorphic ventricular tachycardia, or …

<p id="p001">Immune checkpoint inhibitors have improved clinical outcomes associated with
numerous cancers, but high-grade, immune-related adverse events can occur, particularly …

Currently available HIV-1 protease inhibitors are potent agents in the therapy of HIV-1
infection. However, limited oral absorption and variable tissue distribution, both of which are …

Cytochrome P450 (CYP)2C19 catalyzes the bioactivation of the antiplatelet prodrug clopidogrel,
and CYP2C19 loss‐of‐function alleles impair formation of active metabolites, resulting …

Motivation: Emergence of genetic data coupled to longitudinal electronic medical records (EMRs)
offers the possibility of phenome-wide association scans (PheWAS) for disease–gene …

… The term repolarization reserve was introduced by Roden, 70 who explained that normal
cardiac … Roden proposed that lesions in these repolarizing mechanisms that result in reduced …

Candidate gene and genome-wide association studies (GWAS) have identified genetic variants
that modulate risk for human disease; many of these associations require further study to …

… Yang T, Roden DM. Extracellular potassium modulation of drug block of Ikr: Implications for
… Yang T, Snyders DJ, Roden DM. Discordance between Iicr block and torsades de pointes. (…

Our objective was to develop a DNA biobank linked to phenotypic data derived from an
electronic medical record (EMR) system. An “opt‐out” model was implemented after significant …