Positive allosteric modulators as an approach to nicotinic acetylcholine receptor-targeted therapeutics: advantages and limitations
DK Williams, J Wang, RL Papke - Biochemical pharmacology, 2011 - Elsevier
Neuronal nicotinic acetylcholine receptors (nAChR), recognized targets for drug development
in cognitive and neuro-degenerative disorders, are allosteric proteins with dynamic …
in cognitive and neuro-degenerative disorders, are allosteric proteins with dynamic …
[HTML][HTML] Purposeful selection of variables in logistic regression
Z Bursac, CH Gauss, DK Williams… - Source code for biology …, 2008 - Springer
Background The main problem in many model-building situations is to choose from a large
set of covariates those that should be included in the "best" model. A decision to keep a …
set of covariates those that should be included in the "best" model. A decision to keep a …
[BOOK][B] God's own party: The making of the Christian right
DK Williams - 2012 - books.google.com
… Williams presents the first comprehensive history of the Christian Right, uncovering how
evangelicals came to see the Republican Party as the vehicle through which they could reclaim …
evangelicals came to see the Republican Party as the vehicle through which they could reclaim …
Assessing hospital-associated deaths from discharge data: the role of length of stay and comorbidities
SF Jencks, DK Williams, TL Kay - Jama, 1988 - jamanetwork.com
To assess the meaning of hospital-associated death rates, we studied whether mortality
within 30 days of hospital admission (30-day mortality) is more informative than inpatient …
within 30 days of hospital admission (30-day mortality) is more informative than inpatient …
Cytochrome P450 phenotypic ratios for predicting herb‐drug interactions in humans
…, SF Gardner, MA Hubbard, DK Williams… - Clinical …, 2002 - Wiley Online Library
Objectives Phytochemical‐mediated modulation of cytochrome P450 (CYP) activity may
underlie many herb‐drug interactions. Single‐time point phenotypic metabolic ratios were used …
underlie many herb‐drug interactions. Single‐time point phenotypic metabolic ratios were used …
In vivo effects of goldenseal, kava kava, black cohosh, and valerian on human cytochrome P450 1A2, 2D6, 2E1, and 3A4/5 phenotypes
…, SF Gardner, MA Hubbard, DK Williams… - Clinical …, 2005 - Wiley Online Library
Objectives Phytochemical‐mediated modulation of cytochrome P450 (CYP) activity may
underlie many herb‐drug interactions. Single‐time point phenotypic metabolic ratios were used …
underlie many herb‐drug interactions. Single‐time point phenotypic metabolic ratios were used …
A randomized trial of telemedicine-based collaborative care for depression
JC Fortney, JM Pyne, MJ Edlund, DK Williams… - Journal of general …, 2007 - Springer
Background Evidence-based practices designed for large urban clinics are not necessarily
portable into smaller isolated clinics. Implementing practice-based collaborative care for …
portable into smaller isolated clinics. Implementing practice-based collaborative care for …
Discovery of N-(4-(2-Amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide (BMS-777607), a …
…, BS Wautlet, D Wei, DK Williams… - Journal of medicinal …, 2009 - ACS Publications
Substituted N-(4-(2-aminopyridin-4-yloxy)-3-fluoro-phenyl)-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamides
were identified as potent and selective Met kinase inhibitors. …
were identified as potent and selective Met kinase inhibitors. …
Clinical assessment of effects of botanical supplementation on cytochrome P450 phenotypes in the elderly: St John's wort, garlic oil, Panax ginseng and Ginkgo biloba
BJ Gurley, SF Gardner, MA Hubbard, DK Williams… - Drugs & aging, 2005 - Springer
Objectives Elderly patients are more likely to ingest prescription medications concurrently
with botanical supplements, and may therefore be vulnerable to herb-drug interactions. …
with botanical supplements, and may therefore be vulnerable to herb-drug interactions. …
Practice-based versus telemedicine-based collaborative care for depression in rural federally qualified health centers: a pragmatic randomized comparative …
…, GW Schroeder, DK Williams… - American Journal of …, 2013 - Am Psychiatric Assoc
Objective Practice-based collaborative care is a complex evidence-based practice that is
difficult to implement in smaller primary care practices that lack on-site mental health staff. …
difficult to implement in smaller primary care practices that lack on-site mental health staff. …