Nootropic α7 nicotinic receptor allosteric modulator derived from GABAA receptor modulators

…, MB Tran, DJ Hogenkamp… - Proceedings of the …, 2007 - National Acad Sciences
Activation of brain α7 nicotinic acetylcholine receptors (α7 nAChRs) has broad therapeutic
potential in CNS diseases related to cognitive dysfunction, including Alzheimer's disease and …

Reversible lipidization for the oral delivery of leu-enkephalin

J Wang, DJ Hogenkamp, M Tran, WY Li… - Journal of drug …, 2006 - Taylor & Francis
The endogenous opioid peptide leu-enkephalin (ENK) was chemically modified by a method
known as reversible aqueous lipidization (REAL) with a novel amine-reacting lipophilic …

Enaminone Amides as Novel Orally Active GABAA Receptor Modulators

DJ Hogenkamp, TBC Johnstone… - Journal of medicinal …, 2007 - ACS Publications
A series of enaminone esters and amides have been developed as potent allosteric
modulators of γ-aminobutyric acid A (GABA A ) receptors. The compounds bind to a novel …

Synthesis and in Vitro Activity of 3β-Substituted-3α-hydroxypregnan-20-ones:  Allosteric Modulators of the GABAA Receptor

DJ Hogenkamp, SH Tahir, JE Hawkinson… - Journal of medicinal …, 1997 - ACS Publications
Two naturally occurring metabolites of progesterone, 3α-hydroxy-5α- and 5β-pregnan-20-one
(1 and 2), are potent allosteric modulators of the GABA A receptor. Their therapeutic …

3-(4-Phenoxyphenyl) pyrazoles: a novel class of sodium channel blockers

…, RM Woodward, DJ Hogenkamp - Journal of medicinal …, 2004 - ACS Publications
A series of 3-(4-phenoxyphenyl)-1H-pyrazoles were synthesized and characterized as
potent state-dependent sodium channel blockers. A limited SAR study was carried out to …

Limiting activity at β1-subunit-containing GABAA receptor subtypes reduces ataxia

KW Gee, MB Tran, DJ Hogenkamp… - … of Pharmacology and …, 2010 - ASPET
GABA A receptor (R) positive allosteric modulators that selectively modulate GABA A Rs
containing β 2 - and/or β 3 - over β 1 -subunits have been reported across diverse chemotypes. …

Modifying quinolone antibiotics yields new anxiolytics

TBC Johnstone, DJ Hogenkamp, L Coyne, J Su… - Nature medicine, 2004 - nature.com
Patients taking fluoroquinolone antibiotics such as norfloxacin exhibit a low incidence of
convulsions and anxiety. These side effects probably result from antagonism of the …

Allosteric modulation of nicotinic and GABAA receptor subtypes differentially modify autism-like behaviors in the BTBR mouse model

RF Yoshimura, MB Tran, DJ Hogenkamp, NL Ayala… - …, 2017 - Elsevier
… 313 and 4–327) were prepared as described in the literature (Hogenkamp et al., 2007).
AVL-3288 (also … Gee KW, Johnstone T and Hogenkamp DJ are inventors on patents covering the …

Negative allosteric modulation of nicotinic acetylcholine receptors blocks nicotine self-administration in rats

RF Yoshimura, DJ Hogenkamp, WY Li, MB Tran… - … of Pharmacology and …, 2007 - ASPET
Drugs that antagonize nicotinic acetylcholine receptors (nAChRs) can be used to inhibit
nicotine-induced behavior in both humans and animals. The aim of our experiments is to …

Allosteric modulators of the δ GABAA receptor subtype demonstrate a therapeutic effect in morphine-antinociceptive tolerance and withdrawal in mice

…, BP Doan, TB Johnstone, DJ Hogenkamp… - …, 2022 - Elsevier
The present study evaluated the effects of compounds targeting extrasynaptic δ subunit-containing
γ-aminobutyric acid type A receptors (δ*-GABA A Rs) to interrogate the role of tonic …