Although the cellular mechanisms of pharmacological actions of gabapentin (Neurontin ® )
remain incompletely described, several hypotheses have been proposed. It is possible that …

The term ‘Ca 2+ channel α 2 δ ligands' has recently been applied to an evolving drug class
that includes gabapentin (Neurontin ® ) and pregabalin (Lyrica ® ), and reflects significant …

Gabapentin and pregabalin (S-(+)-3-isobutylgaba) produced concentration-dependent
inhibitions of the K + -induced [Ca 2+ ] i increase in fura-2-loaded human neocortical …

We describe the first potent and selective blocker of the class E Ca 2+ channel. SNX-482, a
novel 41 amino acid peptide present in the venom of the African tarantula, Hysterocrates …

Gabapentin (GBP; Neurontin) has proven efficacy in several neurological and psychiatric
disorders yet its mechanism of action remains elusive. This drug, and the related compounds …

Gabapentin (Neurontin ® ) has preclinical and clinical efficacy as an anticonvulsant,
antihyperalgesic, anxiolytic, and neuroprotective drug. Since l-glutamic acid (GLU) is involved in …

… been shown to significantly attenuate K -evoked, Ca2-dependent [3H]-norepinephrine ([3H]-NE)
release from rat neocortical slices at pharmacologically relevant concentrations (Dooley …

Cytosolic calcium ion concentrations ([Ca 2+ ] i ) were measured in rat neocortical synaptosomes
using fura‐2, and depolarization of synaptosomal membranes was induced by K + (30 …

We have recently shown that the anticonvulsant drugs phenytoin, lamotrigine and sodium
valproate all reduce the release of glutamate at synapses in the entorhinal cortex in vitro. In …

CGP 20712 A (1-[2-((3-carbamoyl-4-hydroxy)phenoxy)ethylamino]-3-[4-(1-methyl-4-trifluoromethyl-2-imidazolyl)
phenoxyl]-2-propanol methanesulfonate), a specific β 1 -adrenoceptor …