Pathophysiology and management of hypokalemia: a clinical perspective

RJ Unwin, FC Luft, DG Shirley - Nature Reviews Nephrology, 2011 - nature.com
Potassium (K + ) ions are the predominant intracellular cations. K + homeostasis depends on
external balance (dietary intake [typically 100 mmol per day] versus excretion [95% via the …

An overview of divalent cation and citrate handling by the kidney

RJ Unwin, G Capasso, DG Shirley - Nephron Physiology, 2004 - karger.com
Urinary calcium, magnesium and citrate levels are important in promoting or inhibiting renal
stone formation. Here we review current information on the tubular handling of these ions. …

[HTML][HTML] Urinary acidification assessed by simultaneous furosemide and fludrocortisone treatment: an alternative to ammonium chloride

SB Walsh, DG Shirley, OM Wrong, RJ Unwin - Kidney international, 2007 - Elsevier
Distal renal tubular acidosis (RTA) can lead to rickets in children or osteomalacia in adults if
undetected. This disorder is normally diagnosed by means of an oral ammonium chloride-…

The validity of lithium clearance as an index of sodium and water delivery from the proximal tubules

K Thomsen, DG Shirley - Nephron, 1997 - search.proquest.com
Shirley DG: Renal tubular lithium reabsorption in anaesthetizcd, potassium-depleted rats.
J … Shirley DG: Changes in proximal tubular function following unilateral nephrectony. Acta …

Natriuretic effect of caffeine: assessment of segmental sodium reabsorption in humans

DG Shirley, SJ Walter, FH Noormohamed - Clinical Science, 2002 - portlandpress.com
In order to assess the intrarenal mechanisms responsible for the natriuretic action of caffeine,
the renal clearances of 51 Cr-EDTA [used as a measure of glomerular filtration rate (GFR)] …

Acute and chronic changes in renal function following unilateral nephrectomy

DG Shirley, SJ Walter - Kidney international, 1991 - Elsevier
… WALTER SJ, SHIRLEY DO: Changes in proximal tubular function following unilateral …
WALTER SJ, SHIRLEY DO: The effect of chronic hydrochlorothiazide administration on …

Mechanism of compensatory renal hypertrophy

SE Dicker, DG Shirley - The Journal of Physiology, 1971 - Wiley Online Library
… SE DICKER AND DG SHIRLEY the second day after the operation GFR had doubled
itspreoperative value. From the third day onwards, values for inulin clearances decreased until they …

Sodium-dependent regulation of renal amiloride-sensitive currents by apical P2 receptors

…, BF King, DG Shirley… - Journal of the …, 2008 - journals.lww.com
The epithelial sodium channel (ENaC) plays a major role in the regulation of sodium balance
and BP by controlling Na+ reabsorption along the renal distal tubule and collecting duct (…

Immunolocalization of ectonucleotidases along the rat nephron

RM Vekaria, DG Shirley, J Sévigny… - American Journal of …, 2006 - journals.physiology.org
Evidence is accumulating that extracellular nucleotides act as autocrine/paracrine agents in
most tissues, including the kidneys. Several families of surface-located enzymes, collectively …

Ectonucleotidases in the kidney

DG Shirley, RM Vekaria, J Sévigny - Purinergic Signalling, 2009 - Springer
Members of all four families of ectonucleotidases, namely ectonucleoside triphosphate
diphosphohydrolases (NTPDases), ectonucleotide pyrophosphatase/phosphodiesterases (NPPs)…