Guggulsterone activates multiple nuclear receptors and induces CYP3A gene expression through the pregnane X receptor

DE Brobst, X Ding, KL Creech, B Goodwin… - … of Pharmacology and …, 2004 - ASPET
Gugulipid is an extract of the guggul tree, Commiphora mukul, that is used to treat hyperlipidemia
in humans. The lipid-lowering activity is found in the stereoisomers and plant sterols Z-…

[HTML][HTML] p53 selectively regulates developmental apoptosis of rod photoreceptors

L Vuong, DE Brobst, I Ivanovic, DM Sherry… - PLoS …, 2013 - journals.plos.org
Retinal cells become post-mitotic early during post-natal development. It is likely that p53, a
well-known cell cycle regulator, is involved in regulating the genesis, differentiation and …

[HTML][HTML] Pattern of expression of p53, its family members, and regulators during early ocular development and in the post-mitotic retina

L Vuong, DE Brobst, A Saadi, I Ivanovic… - … & visual science, 2012 - iovs.arvojournals.org
Purpose.: Because of its role in cell cycle regulation and apoptosis, p53 may be involved in
maintaining the post-mitotic state of the adult eye. To shed light on the role of p53 in retinal …

A vapor exposure model for neonatal mice

DR Anderson, LW Mitcheltree, DE Brobst… - Toxicology …, 2002 - Taylor & Francis
… In this article, we describe modifications of the vapor cup model of Mershon and colleagues
(1990) to establish a new vapor cup model for use in neonatal mice. The need to develop …

[BOOK][B] United States mineral resources

DA Brobst, WP Pratt - 1973 - books.google.com
… The source of the barite in residual deposits generally has been assumed to be epigenetic
(introduced) hydrothermal vein material left after the host rock has been chemically destroyed…

Evaluation of two novel models to examine the human xenobiotic-response: An immortalized human hepatocyte cell line and a 'humanized'pregnane X receptor …

DE Brobst - 2006 - search.proquest.com
… The Thesis Committee for Daniel Brobst certifies that this is the approved version of the …
anti-inflammatory drugs like ibuprofen (Goldstein and de Morais, 1994; Miners and Birkett, 1998; …

[BOOK][B] Knock Until the Dog Barks: An Adventure in Puerto Vallarta

DE Brobst - 2013 - books.google.com
Two American families find themselves entangled in Puerto Villarta's Romantic Zone, a
symbiotic place where tourists thrive and imbibe in excellent dining, exciting nightlife, and …

[PDF][PDF] On The Mechanism Of Protection Against Sulfur Mustard Injury By Inhibition Of Poly (Adp-Ribose) Polymerase

R Ray, BJ Benton, DR Anderson, DE Brobst, JP Petrali… - researchgate.net
It has been demonstrated that niacinamide, which is an inhibitor of the enzyme poly (ADP-ribose)
polymerase (PARP), partially protects against sulfur mustard (HD) vapor-induced skin …

1H- and 13C-nmr Assignments for Taxol, 7-epi-Taxol, and Cephalomannine

GN Chmurny, BD Hilton, S Brobst, SA Look… - Journal of natural …, 1992 - ACS Publications
… Its mechanism of action has been shown to involve interference with tubulin de-polymerization
(1). As a first step toward understanding structural requirements for the biological action of …

Rapid high-resolution separation of oligosaccharides on silver form cation-exchange resins

HD Scobell, KM Brobst - Journal of Chromatography A, 1981 - Elsevier
… While the resolution of the separation is generally excellent for dextrose and maltose, the
resolution of the higher corn-derived oligosaccharides deteriorates markedly after maltotriose …