Since the discovery of p38 MAP kinase in 1994, our understanding of its biology has progressed
dramatically. The key advances include (1) identification of p38 MAP kinase homologs …

The effects of a second generation p38 mitogen-activated protein kinase (MAPK) inhibitor,
SB 239063 [trans-1-(4-hydroxycyclohexyl)-4-(4-fluorophenyl)-5-(2-methoxypyridimidin-4-yl)…

The anti-inflammatory/antiallergic activity of a novel second-generation p38 mitogen-activated
protein kinase inhibitor, SB 239063 [trans-1-(4-hydroxycyclohexyl)-4-(4-fluorophenyl)-5-(2-…

The anaphylatoxin C3a is a potent chemotactic peptide and inflammatory mediator released
during complement activation which binds to and activates a G-protein-coupled receptor. …

Evaluation of a variety of PDE4 inhibitors in a series of cellular and in vivo assays suggested
a strategy to improve the therapeutic index of PDE4 inhibitors by increasing their selectivity …

Phosphodiesterase 4 (PDE4) is member of the growing family of proteins that regulate the
intracellular concentrations of cyclic AMP and cyclic GMP. Earliest described inhibitors of …

Aerosolized cysteinyl leukotrienes (CysLTs) elicit migration of eosinophils into guinea pig
lungs and the airways of patients with asthma. The present studies were designed to analyze …

In this study, the activity of the δ-opioid receptor subtype-selective agonist, SB 227122, was
investigated in a guinea pig model of citric acid-induced cough. Parenteral administration of …

Selective inhibition of phosphodiesterase (PDE) isozymes has been shown to inhibit
inflammatory cell function and relax airway smooth muscle and, thus, may be useful in the therapy …

Selective inhibition of the low Km cyclic AMP-specific phosphodiesterase has been shown
to inhibit inflammatory cell function and relax airway smooth muscle. These studies were …