A variety of antioxidant compounds derived from natural products (nutraceuticals) have
demonstrated neuroprotective activity in either in vitro or in vivo models of neuronal cell death or …

The Rho family of GTPases belongs to the Ras superfamily of low molecular weight (∼21
kDa) guanine nucleotide binding proteins. The most extensively studied members are RhoA, …

… Aktories & DA Linseman: Rho family GTPase inhibition reveals opposing effects of
mitogenactivated protein kinase kinase/extracellular signalregulated kinase and Janus kinase/signal …

Glycogen synthase kinase-3β (GSK-3β) is a critical activator of neuronal apoptosis induced
by a diverse array of neurotoxic insults. However, the downstream substrates of GSK-3β that …

Signaling cascades elicited by angiotensin II resemble those characteristic of growth factor
stimulation. In this report, we demonstrate that angiotensin II converges with platelet-derived …

Thromboxane A2 stimulation of smooth muscle cells contributes to the development of
vascular lesions after percutaneous transluminal coronary angioplasty. In view of this, we …

… Loucks FA, Le SS, Zimmermann AK, Ryan KR, Barth H, Aktories K, and Linseman DA. Rho
family GTPase inhibition reveals opposing effects of mitogen-activated protein kinase kinase/…

Bcl-2 protects cells against mitochondrial oxidative stress and subsequent apoptosis.
However, the mechanism underlying the antioxidant function of Bcl-2 is currently unknown. …

Anthocyanins are being increasingly investigated for their neuroprotective and
antineuroinflammatory effects; however, the overall bioavailability of many anthocyanins is relatively …

In vivo, the pesticide rotenone induces degeneration of dopamine neurons and parkinsonian‐like
pathology in adult rats. In the current study, we utilized primary ventral mesencephalic (…