The identification and cloning of the two major cannabinoid (CB 1 and CB 2 ) receptors together
with the discovery of their endogenous ligands in the late 80s and early 90s, resulted in …

Cannabinoids act via cell surface G protein-coupled receptors (CB 1 and CB 2 ) and the ion
channel receptor TRPV1. Evidence has now emerged suggesting that an additional target is …

… and Kaiser, 1988), phenylalanine (Rusch and Kendall, 1992) and sequences of mixed amino
acid composition (Goldstein et ai, 1990); these have all proved more efficient than their wild…

Scientists who plan to publish in British Journal of Pharmacology (BJP) must read this article
before undertaking a study. This editorial provides guidance for the design of experiments. …

… (DA) concentrations and an altered symmetry in DA function in … Isolates showed greater
increases in extracellular DA and … of either dopamine (DA), dihydroxyphenylacetic acid (DOPAC)…

Introduction Cannabis-based medicines have a number of therapeutic indications, including
anti-inflammatory and analgesic effects. The endocannabinoid receptor system, including …

Isolation rearing of rats produces a behavioral syndrome indicative of altered dopamine (DA)
function in the nucleus accumbens (NAC). The present experiments extend these findings …

The ability of the endogenous fatty acid amide, cis‐oleamide (ODA), to bind to and activate
cannabinoid CB 1 and CB 2 receptors was investigated. ODA competitively inhibited binding …

In Escherichia coli, components of a signal recognition particle (SRP) and its receptor have
been identified which appear to be essential for efficient translocation of several proteins. In …

Natural products continue to be an important source of medicines and drug templates. Indeed,
it has been estimated that approximately a third of all Food and Drug Administration (FDA)…