User profiles for C. Sumners

Charlotte Summers

- Verified email at medschl.cam.ac.uk - Cited by 19012

Colin Sumners

- Verified email at ufl.edu - Cited by 14423

Angiotensin II in central nervous system physiology

MI Phillips, C Sumners - Regulatory peptides, 1998 - Elsevier
1. Introduction direct injection of Ang II into the rat brain produced drinking behavior [9] and
indirect measurements showing Exactly one hundred years ago Tiegerstedt and Bergman …

Therapeutic implications of the vasoprotective axis of the renin-angiotensin system in cardiovascular diseases

…, RAS Santos, CN Bradford, AP Mecca, C Sumners… - …, 2010 - Am Heart Assoc
Despite the tremendous success obtained using the current pharmacotherapy, especially
angiotensin (Ang)-converting enzyme (ACE) inhibitors (ACEis) and Ang II receptor blockers (…

The angiotensin AT2 receptor: from a binding site to a novel therapeutic target

…, T Unger, A Hallberg, RM Carey, C Sumners - Pharmacological …, 2022 - ASPET
Discovered more than 30 years ago, the angiotensin AT 2 receptor (AT 2 R) has evolved
from a binding site with unknown function to a firmly established major effector within the …

Brain microglial cytokines in neurogenic hypertension

…, Q Li, S Sriramula, J Francis, C Sumners… - …, 2010 - Am Heart Assoc
… It has been shown to inhibit protein kinase C-α phosphorylation and nuclear translocation
of protein kinase C-α/βΙΙ and interferon-γ regulatory factor, which further inhibit class II activator…

Effect of exercise training on blood pressure in 70-to 79-yr-old men and women.

…, ML Pollock, MI Phillips, C Sumners… - Medicine and science …, 1991 - europepmc.org
Men and women 70-79 yr of age (N= 49) were studied to assess the effect of 6 months of
resistance or endurance exercise training on their blood pressure, hemodynamic parameters, …

Cerebroprotection by angiotensin‐(1–7) in endothelin‐1‐induced ischaemic stroke

…, MK Raizada, MJ Katovich, C Sumners - Experimental …, 2011 - Wiley Online Library
C, D and E are representative fluorescence micrographs showing NeuN immunoreactivity
co-localized with DAPI nuclear stain (pink coloured cells; red NeuN + blue DAPI) in the …

Chronic ethanol exposure potentiates NMDA excitotoxicity in cerebral cortical neurons

LJ Chandler, H Newsom, C Sumners… - Journal of …, 1993 - Wiley Online Library
… Cells were incubated at 37C in a humidified incubator with 5% C02/95% air for 3 days and
were then treated with 10 pM &cytosine arabinoside (ARC) in fresh DMEM containing 10% …

The angiotensin II type 2 receptor: an enigma with multiple variations

…, MK Raizada, C Sumners - American Journal of …, 2000 - journals.physiology.org
… The growth-suppressing effects that are mediated by AT 2 receptors do not involve repression
of c-fos and c-jun gene expression (134) but are mediated through the inhibition of cyclin …

Anti-inflammatory effects of angiotensin-(1-7) in ischemic stroke

…, DJ Pioquinto, A Afzal, J Mocco, C Sumners - …, 2013 - Elsevier
… then centrifuged at 4 C for 30 min at 16.1 g. Supernatants were frozen at −20 C, until analysis
… After heating for 5 min at 90 C, samples were loaded into a precast TGX Criterion gel (Bio-…

[HTML][HTML] Genetic mechanisms of critical illness in COVID-19

, … , Cardiff, UK Lynch C. 93 Pothecary C. 93 Roche L. 93 … - Nature, 2021 - nature.com
Host-mediated lung inflammation is present 1 , and drives mortality 2 , in the critical illness
caused by coronavirus disease 2019 (COVID-19). Host genetic variants associated with …