Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits
…, N Amin, DE Arking, KL Ayers, CM Barbieri… - Nature …, 2018 - nature.com
High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease.
We report the largest genetic association study of blood pressure traits (systolic, diastolic …
We report the largest genetic association study of blood pressure traits (systolic, diastolic …
Genetic insights into biological mechanisms governing human ovarian ageing
…, A Augustinsson, S Bandinelli, CM Barbieri… - Nature, 2021 - nature.com
Reproductive longevity is essential for fertility and influences healthy ageing in women 1 , 2
, but insights into its underlying biological mechanisms and treatments to preserve it are …
, but insights into its underlying biological mechanisms and treatments to preserve it are …
Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk
…, E Albrecht, E Altmaier, M Amini, CM Barbieri… - Nature …, 2017 - nature.com
The timing of puberty is a highly polygenic childhood trait that is epidemiologically associated
with various adult diseases. Using 1000 Genomes Project–imputed genotype data in up to …
with various adult diseases. Using 1000 Genomes Project–imputed genotype data in up to …
Atomic resolution mechanistic studies of ribocil: A highly selective unnatural ligand mimic of the E. coli FMN riboswitch
…, H Tang, A Villafania, R Zhang, CM Barbieri… - RNA biology, 2016 - Taylor & Francis
Bacterial riboswitches are non-coding RNA structural elements that direct gene expression
in numerous metabolic pathways. The key regulatory roles of riboswitches, and the urgent …
in numerous metabolic pathways. The key regulatory roles of riboswitches, and the urgent …
Selective small-molecule inhibition of an RNA structural element
…, A Villafania, A Nahvi, N Murgolo, CM Barbieri… - Nature, 2015 - nature.com
… Electroporation reactions were performed using 0.1-cm gap cuvettes and a GenePulser II
(BioRad) with settings at 200 Ω, 25 μF, and 1.8 kV. Cells were recovered at the appropriate …
(BioRad) with settings at 200 Ω, 25 μF, and 1.8 kV. Cells were recovered at the appropriate …
[HTML][HTML] Dissecting the role of H3K27 acetylation and methylation in PRC2 mediated control of cellular identity
E Lavarone, CM Barbieri, D Pasini - Nature communications, 2019 - nature.com
… mESCs were induced to differentiate to EBs by LIF removal in hanging drops (1000 cells/20
μl drop) on the lid of 15 cm petri dishes for 48 h. EBs were then collected and stimulated with …
μl drop) on the lid of 15 cm petri dishes for 48 h. EBs were then collected and stimulated with …
Novel blood pressure locus and gene discovery using genome-wide association study and expression data sets from blood and the kidney
Elevated blood pressure is a major risk factor for cardiovascular disease and has a substantial
genetic contribution. Genetic variation influencing blood pressure has the potential to …
genetic contribution. Genetic variation influencing blood pressure has the potential to …
Universally applicable methods for monitoring response regulator aspartate phosphorylation both in vitro and in vivo using Phos-tag-based reagents
CM Barbieri, AM Stock - Analytical biochemistry, 2008 - Elsevier
… A quartz cell with a 1-cm path length in both the excitation and the emission directions was
used for all measurements. The emission profile of a 10 μM solution of PhoB in 50 mM Tris, …
used for all measurements. The emission profile of a 10 μM solution of PhoB in 50 mM Tris, …
[PDF][PDF] Structure of the Staphylococcus aureus AgrA LytTR domain bound to DNA reveals a beta fold with an unusual mode of binding
DJ Sidote, CM Barbieri, T Wu, AM Stock - Structure, 2008 - cell.com
The LytTR domain is a DNA-binding motif found within the AlgR/AgrA/LytR family of transcription
factors that regulate virulence factor and toxin gene expression in pathogenic bacteria. …
factors that regulate virulence factor and toxin gene expression in pathogenic bacteria. …
Thermodynamics of aminoglycoside–rRNA recognition
DS Pilch, M Kaul, CM Barbieri… - … : Original Research on …, 2003 - Wiley Online Library
2-Deoxystreptamine (2-DOS) aminoglycosides are a family of structurally related broad-spectrum
antibiotics that are used widely in the treatment of infections caused by aerobic Gram-…
antibiotics that are used widely in the treatment of infections caused by aerobic Gram-…