Getting to the heart of Alzheimer disease
…, JM Adelstein, F Del Monte, CK Combs… - Circulation …, 2019 - Am Heart Assoc
In a somewhat narrow diagnostic lens, Alzheimer disease (AD) has been considered a brain-specific
disease characterized by the presence of Aβ (β-amyloid) plaques and tau neural …
disease characterized by the presence of Aβ (β-amyloid) plaques and tau neural …
Inflammatory mechanisms in neurodegeneration
…, JJ Neher, ME Tremblay, CK Combs - Journal of …, 2019 - Wiley Online Library
… Combs and colleagues demonstrated that oligomers were better than fibrils at stimulating
IL-6 in murine microglia, yet the reverse was true for stimulating keratinocyte chemoattractant …
IL-6 in murine microglia, yet the reverse was true for stimulating keratinocyte chemoattractant …
Expression and function of APP and its metabolites outside the central nervous system
KL Puig, CK Combs - Experimental gerontology, 2013 - Elsevier
Amyloid precursor protein (APP) derived amyloid beta (Aβ) peptides have been extensively
investigated in Alzheimer's disease pathology of the brain. However, the function of full …
investigated in Alzheimer's disease pathology of the brain. However, the function of full …
β-Amyloid stimulation of microglia and monocytes results in TNFα-dependent expression of inducible nitric oxide synthase and neuronal apoptosis
CK Combs, JC Karlo, SC Kao… - Journal of …, 2001 - Soc Neuroscience
Reactive microglia associated with the β-amyloid plaques in Alzheimer's disease (AD)
brains initiate a sequence of inflammatory events integral to the disease process. We have …
brains initiate a sequence of inflammatory events integral to the disease process. We have …
Inflammatory mechanisms in Alzheimer's disease: inhibition of β-amyloid-stimulated proinflammatory responses and neurotoxicity by PPARγ agonists
CK Combs, DE Johnson, JC Karlo… - Journal of …, 2000 - Soc Neuroscience
Alzheimer's disease (AD) is characterized by the extracellular deposition of β-amyloid fibrils
within the brain and the subsequent association and phenotypic activation of microglial cells …
within the brain and the subsequent association and phenotypic activation of microglial cells …
Cellular and molecular mechanisms of glial scarring and progressive cavitation: in vivo and in vitroanalysis of inflammation-induced secondary injury after CNS …
MT Fitch, C Doller, CK Combs… - Journal of …, 1999 - Soc Neuroscience
Post-traumatic cystic cavitation, in which the size and severity of a CNS injury progress from
a small area of direct trauma to a greatly enlarged secondary injury surrounded by glial scar …
a small area of direct trauma to a greatly enlarged secondary injury surrounded by glial scar …
Identification of microglial signal transduction pathways mediating a neurotoxic response to amyloidogenic fragments of β-amyloid and prion proteins
CK Combs, DE Johnson, SB Cannady… - Journal of …, 1999 - Soc Neuroscience
Microglial interaction with amyloid fibrils in the brains of Alzheimer’s and prion disease patients
results in the inflammatory activation of these cells. We observed that primary microglial …
results in the inflammatory activation of these cells. We observed that primary microglial …
β-Amyloid-stimulated microglia induce neuron death via synergistic stimulation of tumor necrosis factor α and NMDA receptors
AM Floden, S Li, CK Combs - Journal of Neuroscience, 2005 - Soc Neuroscience
Although abundant reactive microglia are found associated with β-amyloid (Aβ) plaques in
Alzheimer's disease (AD) brains, their contribution to cell loss remains speculative. A variety …
Alzheimer's disease (AD) brains, their contribution to cell loss remains speculative. A variety …
[HTML][HTML] Beta amyloid oligomers and fibrils stimulate differential activation of primary microglia
CM Sondag, G Dhawan, CK Combs - Journal of neuroinflammation, 2009 - Springer
Background Beta amyloid (Aβ) peptides are the major constituents of the senile plaques
present in Alzheimer's diseased brain. Pathogenesis has been associated with the aggregated …
present in Alzheimer's diseased brain. Pathogenesis has been associated with the aggregated …
β-Amyloid fibrils activate parallel mitogen-activated protein kinase pathways in microglia and THP1 monocytes
DR McDonald, ME Bamberger, CK Combs… - Journal of …, 1998 - Soc Neuroscience
The senile plaques of Alzheimer’s disease are foci of local inflammatory responses, as
evidenced by the presence of acute phase proteins and oxidative damage. Fibrillar forms of β-…
evidenced by the presence of acute phase proteins and oxidative damage. Fibrillar forms of β-…