A novel binding site for ADAMTS13 constitutively exposed on the surface of globular VWF
S Zanardelli, ACK Chion, E Groot… - Blood, The Journal …, 2009 - ashpublications.org
ADAMTS13 metalloprotease regulates the multimeric size of von Willebrand factor (VWF) by
cleaving the Tyr1605-Met1606 bond in the VWF A2 domain. The mechanisms of VWF …
cleaving the Tyr1605-Met1606 bond in the VWF A2 domain. The mechanisms of VWF …
N-linked glycosylation of VWF modulates its interaction with ADAMTS13
TAJ McKinnon, ACK Chion… - Blood, The Journal …, 2008 - ashpublications.org
We examined the role of N-linked glycan structures of VWF on its interaction with ADAMTS13.
PNGase F digestion followed by lectin analysis demonstrated that more than 90% of VWF …
PNGase F digestion followed by lectin analysis demonstrated that more than 90% of VWF …
Cloning, Expression, and Site-Directed Mutagenesis of the Propene Monooxygenase Genes from Mycobacterium sp. Strain M156
CK Chan Kwo Chion, SE Askew… - Applied and …, 2005 - Am Soc Microbiol
Propene monooxygenase has been cloned from Mycobacterium sp. strain M156, based on
hybridization with the amoABCD genes of Rhodococcus corallinus B276. Sequencing …
hybridization with the amoABCD genes of Rhodococcus corallinus B276. Sequencing …
Cloning and expression of the genes encoding the propene monooxygenase from Xanthobacter, Py2
NY Zhou, CK Chan Kwo Chion, DJ Leak - Applied microbiology and …, 1996 - Springer
Xanthobacter Py2 grows on propene as sole carbon source, converting propene to propene
oxide (epoxypropane) using an alkene-specific monooxygenase, as the first step in …
oxide (epoxypropane) using an alkene-specific monooxygenase, as the first step in …
Initial Characterization of the Enzyme and Cloning of Genes Involved in the Enantioselective Epoxyalkane Degradation by Xanthobacter PY2
J Swaving, C Weijers, CKCK Chion, DJ Leak… - Biocatalysis, 1994 - Taylor & Francis
The epoxyalkane-degrading enzyme of Xanthobacter Py2 was studied in crude extracts. NAD
and a low molecular weight fraction which can be replaced by DTT are necessary for the …
and a low molecular weight fraction which can be replaced by DTT are necessary for the …
ADAMTS13 and von Willebrand factor and the risk of myocardial infarction in men
CKNK Chion, CJM Doggen, JTB Crawley, DA Lane… - Blood, 2007 - ashpublications.org
Von Willebrand factor (VWF) mediates the tethering/adhesion of platelets at sites of vascular
injury. This function depends on its multimeric size, which is controlled by ADAMTS13. We …
injury. This function depends on its multimeric size, which is controlled by ADAMTS13. We …
Evidence for the Interaction Between VWF Carboxyl-Terminal Domains and ADAMTS13 Domains Distal to Its Spacer Domain
S Zanardelli, CK Chion, M Laffan, PJ Lenting, E Groot… - 2008 - ashpublications.org
ADAMTS13 plasma metalloprotease regulates the multimeric size of von Willebrand factor (VWF)
by cleaving the Y1605-M1606 bond in the A2 domain. Several studies have …
by cleaving the Y1605-M1606 bond in the A2 domain. Several studies have …
[HTML][HTML] The Role of N-Linked Glycosylation in Expression and Function of ADAMTS13
A Nowak, CK Chion, M Laffan, TAJ McKinnon - Blood, 2008 - Elsevier
N-linked glycosylation is an important co-translational protein modification affecting protein
folding, secretion, stability & function. We have previously demonstrated that N-linked …
folding, secretion, stability & function. We have previously demonstrated that N-linked …
The Effect of Von Willebrand Factor Glycans on the Interaction with ADAMTS13.
TAJ McKinnon, ACK Chion, MA Laffan - 2006 - ashpublications.org
Von Willebrand factor (VWF) is a large plasma glycoprotein that mediates platelet tethering
at sites of vascular injury. This function is dependent upon its multimeric size, which is …
at sites of vascular injury. This function is dependent upon its multimeric size, which is …
A functional calcium-binding site in the metalloprotease domain of ADAMTS13
MD Gardner, CKNK Chion, R de Groot… - Blood, The Journal …, 2009 - ashpublications.org
ADAMTS13 regulates the multimeric size of von Willebrand factor (VWF). Its function is highly
dependent upon Ca 2+ ions. Using the initial rates of substrate (VWF115, VWF residues …
dependent upon Ca 2+ ions. Using the initial rates of substrate (VWF115, VWF residues …