[PDF][PDF] Identification and purification of an adrenal medullary protein (synexin) that causes calcium-dependent aggregation of isolated chromaffin granules.

CE Creutz, CJ Pazoles, HB Pollard - Journal of Biological …, 1978 - researchgate.net
We have isolated from the adrenal medulla a protein which causes the aggregation of isolated
chromaffin granules when incubated in the presence of free calcium at concentrations …

[HTML][HTML] Novel role for glutathione S-transferase π: regulator of protein S-glutathionylation following oxidative and nitrosative stress

…, Y Manevich, L He, S Hutchens, CJ Pazoles… - Journal of biological …, 2009 - ASBMB
Glutathione S-transferase Pi (GSTπ) is a marker protein in many cancers and high levels
are linked to drug resistance, even when the selecting drug is not a substrate. S-…

Alkylphosphocholine analogs for broad-spectrum cancer imaging and therapy

…, AM Traynor, HE Chen, LT Hall, CJ Pazoles… - Science translational …, 2014 - science.org
Many solid tumors contain an overabundance of phospholipid ethers relative to normal cells.
Capitalizing on this difference, we created cancer-targeted alkylphosphocholine (APC) …

NOV-002, a glutathione disulfide mimetic, as a modulator of cellular redox balance

…, L He, S Hutchens, TE Garrett, CJ Pazoles… - Cancer research, 2008 - AACR
NOV-002 is a novel glutathione disulfide mimetic that when administered in combination
with standard chemotherapeutic regimens has resulted in increased efficacy (survival, tumor …

[HTML][HTML] Self-association of synexin in the presence of calcium. Correlation with synexin-induced membrane fusion and examination of the structure of synexin …

CE Creutz, CJ Pazoles, HB Pollard - Journal of Biological Chemistry, 1979 - Elsevier
… evidence for the anion requirement and the role of osmotic lysis in exocytosis is presented
in Pazoles and Pollard, 1978; Pollard et al., 1977; and Brown et al., 1978). We now present a …

[PDF][PDF] Internal pH and state of ATP in adrenergic chromaffin granules determined by 31P nuclear magnetic resonance spectroscopy.

…, H Shindo, CE Creutz, CJ Pazoles… - Journal of Biological …, 1979 - researchgate.net
MATERIALS AND METHODS Purification of Chromaffin Granules-Bovine adrenal glands
were obtained at a local slaughter house within 30 min of slaughter, placed on ice, and …

The glutathione disulfide mimetic NOV-002 inhibits cyclophosphamide-induced hematopoietic and immune suppression by reducing oxidative stress

…, L Shao, W Feng, AA Zidan, CJ Pazoles… - Free Radical Biology …, 2012 - Elsevier
The oxidized glutathione mimetic NOV-002 is a unique anti-tumor agent that not only has the
ability to inhibit tumor cell proliferation, survival, and invasion, but in some settings can also …

The chromaffin granule and possible mechanisms of exocytosis

HB Pollard, CJ Pazoles, CE Creutz, O Zinder - International review of …, 1979 - Elsevier
… Catalase has also been detected in particulate fractions of adrenal medulla (CJ Pazoles,
E. Weinbach, and HB Pollard, unpublished observations). Thus the chromaffin granule has …

Tenidap modulates cytoplasmic pH and inhibits anion transport in vitro. II. Inhibition of IL-1 beta production from ATP-treated monocytes and macrophages.

…, D Perregaux, L Svensson, CJ Pazoles… - … (Baltimore, Md.: 1950 …, 1994 - journals.aai.org
IL-1 beta is an important inflammatory mediator produced by monocytes and macrophages
after LPS stimulation. In the absence of a secondary stimulus, however, little IL-1 beta is …

NOV-002, a mimetic of glutathione disulfide

DM Townsend, CJ Pazoles, KD Tew - Expert opinion on …, 2008 - Taylor & Francis
Background: Oxidative signaling to modulate redox-sensitive cell functions is a heretofore
unexploited approach to developing new drugs for poorly treated oncology indications, where …