User profiles for C. J. Hauser
 | Carl J Hauserprofessor of surgery Harvard university Verified email at bidmc.harvard.edu Cited by 14527 |
Circulating mitochondrial DAMPs cause inflammatory responses to injury
Injury causes a systemic inflammatory response syndrome (SIRS) that is clinically much like
sepsis 1 . Microbial pathogen-associated molecular patterns (PAMPs) activate innate …
sepsis 1 . Microbial pathogen-associated molecular patterns (PAMPs) activate innate …
The coagulopathy of trauma: a review of mechanisms
Background: Bleeding is the most frequent cause of preventable death after severe injury.
Coagulopathy associated with severe injury complicates the control of bleeding and is …
Coagulopathy associated with severe injury complicates the control of bleeding and is …
Results of the CONTROL trial: efficacy and safety of recombinant activated Factor VII in the management of refractory traumatic hemorrhage
… Hauser received consulting fees from Novo Nordisk and grant support from NIH/NIGMS. Dr.
… Hauser, Department of Surgery, Beth Israel Deaconess Medical Center, 110 Francis Street, …
… Hauser, Department of Surgery, Beth Israel Deaconess Medical Center, 110 Francis Street, …
Mitochondrial DNA is released by shock and activates neutrophils via p38 map kinase
Bacterial DNA (bDNA) can activate an innate-immune stimulatory" danger “response via toll-like
receptor 9 (TLR9). Mitochondrial DNA (mtDNA) is unique among endogenous …
receptor 9 (TLR9). Mitochondrial DNA (mtDNA) is unique among endogenous …
Prophylactic antibiotic use in open fractures: an evidence-based guideline
CJ Hauser, CA Adams Jr, SR Eachempati - Surgical infections, 2006 - liebertpub.com
Background: Prolonged courses of broad-spectrum antibiotics are often cited as the standard
of care for prevention of infective complications of open fractures. The origins of these …
of care for prevention of infective complications of open fractures. The origins of these …
[HTML][HTML] Mitochondrial DAMPs increase endothelial permeability through neutrophil dependent and independent pathways
…, C Zhao, Y Zheng, H Li, LE Otterbein, CJ Hauser… - PloS one, 2013 - journals.plos.org
Trauma and sepsis can cause acute lung injury (ALI) and Acute Respiratory Distress Syndrome
(ARDS) in part by triggering neutrophil (PMN)-mediated increases in endothelial cell (EC…
(ARDS) in part by triggering neutrophil (PMN)-mediated increases in endothelial cell (EC…
Prospective validation of computed tomographic screening of the thoracolumbar spine in trauma
CJ Hauser, G Visvikis, C Hinrichs… - Journal of Trauma …, 2003 - journals.lww.com
Objective Concern for thoracolumbar spine (TLS) injuries after major trauma mandates
immobilization pending radiographic evaluation. Current protocols use standard posteroanterior …
immobilization pending radiographic evaluation. Current protocols use standard posteroanterior …
[HTML][HTML] Mitochondrial DNA released by trauma induces neutrophil extracellular traps
Neutrophil extracellular traps (NETs) are critical for anti-bacterial activity of the innate immune
system. We have previously shown that mitochondrial damage-associated molecular …
system. We have previously shown that mitochondrial damage-associated molecular …
Health care and socioeconomic impact of falls in the elderly
BACKGROUND: Elderly falls are associated with long hospital stays, major morbidity, and
mortality. We sought to examine the fate of patients ≥75 years of age admitted after falls. …
mortality. We sought to examine the fate of patients ≥75 years of age admitted after falls. …
Bone marrow failure following severe injury in humans
Background: Hematopoietic failure has been observed in experimental animals following
shock and injury. In humans, bone marrow dysfunction has been observed in the red cell …
shock and injury. In humans, bone marrow dysfunction has been observed in the red cell …