This review describes the clinical, etiologic, and physiologic basis of the acute respiratory
distress syndrome and summarizes how its molecular pathogenesis leads to respiratory failure…

… We find values of close to four in red muscle (CA Piantadosi, unpublished observations).
The ability to estimate pathlength in real time is highly desirable but still somewhat impractical …

The extracellular space is protected from oxidant stress by the antioxidant enzyme extracellular
superoxide dismutase (EC-SOD), which is highly expressed in selected tissues including …

The binding of oxygen to heme irons in hemoglobin promotes the binding of nitric oxide (NO)
to cysteineβ93, formingS-nitrosohemoglobin. Deoxygenation is accompanied by an …

Heme oxygenase (HO)-1 is a protective antioxidant enzyme that prevents cardiomyocyte
apoptosis, for instance, during progressive cardiomyopathy. Here we identify a fundamental …

Interactions of nitric oxide (NO) with hemoglobin (Hb) could regulate the uptake and
delivery of oxygen (O 2 ) by subserving the classical physiological responses of hypoxic …

… The rate of ·O 2 − and/or H 2 O 2 production increases as mitochondrial Ca 2+ increases
or pH decreases. Also, the rate of H 2 O 2 production by mitochondria is a function of the …

Carbon monoxide (CO) poisoning is common in modern society, resulting in significant
morbidity and mortality in the United States annually. Over the past two decades, sufficient …

Rationale: We previously reported outcome-associated decreases in muscle energetic status
and mitochondrial dysfunction in septic patients with multiorgan failure. We postulate that …

… Piantadosi. In vivo binding ofcarbon monoxide to … Piantadosi. 1991. Recovery ofenergy
metabolism in rat brain after … Zhang, J., and CA Piantadosi. 1991. Prevention ofH202 generation …