Thioredoxin-1 (Trx-1) is a small redox oncoprotein whose expression is increased in a number
of human primary cancers where it is associated with aggressive tumor growth, inhibition …

Gemcitabine based treatment is currently a standard first line treatment for patients with
advanced pancreatic cancer, however overall survival remains poor, and few options are …

A series of diaryl- and fluorenone-based analogs of the lead compound UA-62784 [4-(5-(4-methoxyphenyl)oxazol-2-yl)-9H-fluoren-9-one]
was synthesized with the intention of …

The inhibitory action and mechanism of inhibition of two types of alpha-glucosidase
inhibitors, acarbose (Bay-g-5421) and 1-deoxynojirimycin derivatives (Bay-m-1099 and Bay-o-1248)…

Purpose Imexon, a pro-oxidant small molecule, has antitumor activity in preclinical models.
The drug induces apoptosis through accumulation of reactive oxygen species. The purpose …

Chronic inflammation increases lymphoma risk. Chronic inflammation exposes cells to
increased reactive oxygen species (ROS). Constant exposure to ROS selects for oxidative stress-…

Oxidative protein folding in the endoplasmic reticulum (ER) requires strict regulation of redox
homeostasis. Disruption of the lumenal redox balance induces an integrated ER stress …

Glucocorticoids are one component of combined treatment regimens for many types of
lymphoma due to their ability to induce apoptosis in lymphoid cells. In WEHI7.2 murine thymic …

Microtubule targeting agents are among the most widely used chemotherapeutics for both
solid and hematological malignancies. This study characterizes the diaryl-oxazole based …

… the combinations of imexon with: a cisplatin, b dacarbazine, c melphalan and d mitomycin. …
3b) and inhibitors of TOPO II such as doxorubicin (Fig. 3c), mitoxantrone and etoposide (Fig. …