[HTML][HTML] Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in …

…, M Schwarz, B Singh, EHK Stelzer, B Stieger… - Archives of …, 2013 - Springer
This review encompasses the most important advances in liver functions and hepatotoxicity
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested, …

Bile salt transporters

PJ Meier, B Stieger - Annual review of physiology, 2002 - annualreviews.org
▪ Abstract Bile salts are the major organic solutes in bile and undergo extensive enterohepatic
circulation. Hepatocellular bile salt uptake is mediated predominantly by the Na + -…

Enterohepatic bile salt transporters in normal physiology and liver disease

GA Kullak-Ublick, B Stieger, PJ Meier - Gastroenterology, 2004 - Elsevier
… , OATP-C and OATP-A are the 2 Na + -independent bile salt uptake systems of human
hepatocytes, whereas OATP8 mediates taurocholate transport to a lesser extent and OATP-B

[HTML][HTML] The sister of P-glycoprotein represents the canalicular bile salt export pump of mammalian liver

T Gerloff, B Stieger, B Hagenbuch, J Madon… - Journal of Biological …, 1998 - ASBMB
Canalicular secretion of bile salts is a vital function of the vertebrate liver, yet the molecular
identity of the involved ATP-dependent carrier protein has not been elucidated. We cloned …

Expression cloning of a rat liver Na (+)-independent organic anion transporter.

E Jacquemin, B Hagenbuch, B Stieger… - Proceedings of the …, 1994 - National Acad Sciences
Using expression cloning in Xenopus laevis oocytes, we have isolated a cDNA encoding a
rat liver organic anion-transporting polypeptide (oatp). The cloned oatp mediated Na(+)-…

St John's Wort induces intestinal P‐glycoprotein/MDR1 and intestinal and hepatic CYP3A4

D Dürr, B Stieger, GA Kullak‐Ublick… - Clinical …, 2000 - Wiley Online Library
… Intestinal P-glycoprotein (A) and CYP3A4/villin (B) expression ratios were determined by
densitometric analysis of Western blots and are given as the geometric means of 3 individual …

Functional expression cloning and characterization of the hepatocyte Na+/bile acid cotransport system.

B Hagenbuch, B Stieger, M Foguet… - Proceedings of the …, 1991 - National Acad Sciences
Liver parenchymal cells continuously extract high amounts of bile acids from portal blood
plasma. This uptake process is mediated by a Na+/bile acid cotransport system. A cDNA …

Identification of a novel human organic anion transporting polypeptide as a high affinity thyroxine transporter

F Pizzagalli, B Hagenbuch, B Stieger… - Molecular …, 2002 - academic.oup.com
Transport of various amphipathic organic compounds is mediated by organic anion transporting
polypeptides (OATPs in humans, Oatps in rodents), which belong to the solute carrier …

Drug-and estrogen-induced cholestasis through inhibition of the hepatocellular bile salt export pump (Bsep) of rat liver

B Stieger, K Fattinger, J Madon, GA Kullak-Ublick… - Gastroenterology, 2000 - Elsevier
Background & Aims: Drug-induced cholestasis is a frequent form of acquired liver disease.
To elucidate the molecular pathogenesis of drug-induced cholestasis, we investigated the …

Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver

GA Kullak-Ublick, B Hagenbuch, B Stieger… - Gastroenterology, 1995 - Elsevier
Background & Aims : Based on a recently cloned rat liver organic anion transporter, we
attempted to clone the corresponding human liver organic anion transporting polypeptide. …