… Rizoska reports employment with Medivir outside the submitted work. Ms. Jansson reports
personal fees from Medivir during the conduct of the study and outside the submitted work. …

Background MIV-711 is a highly potent and selective cathepsin K inhibitor. The current article
summarizes the therapeutic effects of MIV-711 on joint pathology in rabbits subjected to …

Background Cathepsin K is an attractive therapeutic target for diseases in which bone
resorption is excessive such as osteoporosis and osteoarthritis (OA). The current paper …

Cathepsin S inhibitors attenuate mechanical allodynia in preclinical neuropathic pain models.
The current study evaluated the effects when combining the selective cathepsin S inhibitor …

… L-006235 is a potent and selective cathepsin K inhibitor with oral bioavailability and more
than 5000-fold selective for cathepsin K vs cathepsins B, L, and S. L-006235 is potent against …

Mitochondrial DNA encodes 13 proteins that comprise components of the respiratory chain
that maintain oxidative phosphorylation. The replication of mitochondrial DNA is performed …

Purpose: Current treatments for osteoarthritis (OA) target only symptoms, whereas the
disease is characterized by progressive joint structural deterioration. OA is the fastest growing …

Cytarabine (Ara-C) is a nucleotide analog and a cornerstone of standard chemotherapy in
acute myeloid leukemia (AML). 1 Ara-C is phosphorylated to its active metabolite Ara-CTP …

The cytotoxic nucleoside cytarabine (Ara-C) is a cornerstone of AML induction and consolidation
therapies, but drug resistance contributes to disease relapse. Among clinically relevant …

Many systemic chemotherapeutics have failed to show efficacy in hepatocellular carcinoma
(HCC), often because systemic toxicity prevents efficacious liver levels of the drug from …