Hydrogen sulfide generation in mammals: the molecular biology of cystathionine-β-synthase (CBS) and cystathionine-γ-lyase (CSE)

B Renga - Inflammation & Allergy-Drug Targets (Formerly …, 2011 - ingentaconnect.com
… enzyme has a tetrameric structure composed of two dimers (A/B and C/D). The tetramer forms
a … Two catalytic sites are formed at the interface between the subunits A and B, and another …

Role of FXR in regulating bile acid homeostasis and relevance for human diseases

G Rizzo, B Renga, A Mencarelli… - Current Drug Targets …, 2005 - ingentaconnect.com
… (B) Schematic representation of a nuclear receptor: A typical nuclear receptor is composed of
several functional domains. The variable NH2-terminal region (A/B) … the A/B region, and the …

Counter-regulatory role of bile acid activated receptors in immunity and inflammation

…, S Cipriani, A Mencarelli, B Renga… - Current molecular …, 2010 - ingentaconnect.com
… Because IL-1β activates NF-B in hepatocytes, and because NF-B is known to inhibit the …
-B repressors and by GR-induced acetylation of histone H4. It is known that GR and NFB share …

[PDF][PDF] The third gas: H2S regulates perfusion pressure in both the isolated and perfused normal rat liver and in cirrhosis

…, E Antonelli, A Mencarelli, S Orlandi, B Renga… - …, 2005 - Wiley Online Library
… (B) Normal livers produce relatively high endogenous levels of H2S, which are reduced by
exposure to CSE inhibitors, DL-propargylglycine (PAG), and -cyanoalanine (BCA), 1 mmol/L. …

The bile acid receptor FXR is a modulator of intestinal innate immunity

P Vavassori, A Mencarelli, B Renga… - The Journal of …, 2009 - journals.aai.org
The farnesoid X receptor (FXR) is a bile acid-regulated nuclear receptor expressed in
enterohepatic tissues. In this study we investigated whether FXR is expressed by cells of innate …

Inhibition of hydrogen sulfide generation contributes to gastric injury caused by anti-inflammatory nonsteroidal drugs

…, G Rizzo, A Mencarelli, S Orlandi, R Zanardo, B Renga… - Gastroenterology, 2005 - Elsevier
… (B) Production of H 2 S by gastric mucosal homogenates. H 2 S production was assessed
as described in the Materials and Methods section in gastric homogenates incubated with L-…

The nuclear receptor SHP mediates inhibition of hepatic stellate cells by FXR and protects against liver fibrosis

S Fiorucci, E Antonelli, G Rizzo, B Renga, A Mencarelli… - Gastroenterology, 2004 - Elsevier
… (B) Sirius red staining of a liver section obtained from a control rat (original magnification
×40). (C) Liver section from a control rat, showing Sirius red-positive fibrils around the central …

[HTML][HTML] The bile acid receptor GPBAR-1 (TGR5) modulates integrity of intestinal barrier and immune response to experimental colitis

S Cipriani, A Mencarelli, MG Chini, E Distrutti, B Renga… - PloS one, 2011 - journals.plos.org
… The ID for this project is #98/2010-B. The authorization was released to Prof. Stefano … Panel
B. Alcian blue staining of colon sections from 12-month old mice showing a severe reduction …

Evidence that hydrogen sulfide exerts antinociceptive effects in the gastrointestinal tract by activating KATP channels

E Distrutti, L Sediari, A Mencarelli, B Renga… - … of Pharmacology and …, 2006 - ASPET
B, endogenous production of H 2 S by colon and spinal cord homogenates and … (A) without
a significant change of colorectal compliance (B). NaHS administration determines a dose-…

[HTML][HTML] Modulation of intestinal microbiota by the probiotic VSL# 3 resets brain gene expression and ameliorates the age-related deficit in LTP

…, JA O'Reilly, C McDonald, S Cipriani, B Renga… - PloS one, 2014 - journals.plos.org
… from feces of young control rats (YC), young rats administered VSL#3 (YV), aged control
rats (AC) and aged rats administered VSL#3 (AV) from day 0 (panel A) and 42 (panel B)were …