Highly efficient chemical synthesis of 2′-O-methyloligoribonucleotides and tetrabiotinylated derivatives; novel probes that are resistant to degradation by RNA or …
BS Sproat, AI Lamond, B Beijer, P Neuner… - Nucleic Acids …, 1989 - academic.oup.com
… Figure 5 B shows that nuclease PI is also less effective at cleaving 2'-OMe modified RNA
than DNA, although significantly better than micrococcal nuclease. Approximately ten fold more …
than DNA, although significantly better than micrococcal nuclease. Approximately ten fold more …
The pharmacokinetics of cell-penetrating peptides
D Sarko, B Beijer, R Garcia Boy… - Molecular …, 2010 - ACS Publications
… Barbro Beijer … More by Barbro Beijer … Wistar rats were injected with 68 Ga-labeled
penetratin (A), Tat (B) and TP 10 (C) via the tail vein and scanned at 1 h postinjection. …
penetratin (A), Tat (B) and TP 10 (C) via the tail vein and scanned at 1 h postinjection. …
[HTML][HTML] Knowledge architecture supporting the next generation of MDO in the AGILE paradigm
I Van Gent, B Aigner, B Beijer, J Jepsen… - Progress in Aerospace …, 2020 - Elsevier
… 5a and b. Both schemas will ultimately enable a faster integration of the automated
design … The product schema in (b) enables the integration of an arbitrary amount of design …
design … The product schema in (b) enables the integration of an arbitrary amount of design …
[HTML][HTML] How glutaminyl-tRNA synthetase selects glutamine
VL Rath, LF Silvian, B Beijer, BS Sproat, TA Steitz - Structure, 1998 - cell.com
Background: Aminoacyl-tRNA synthetases covalently link a specific amino acid to the
correct tRNA. The fidelity of this reaction is essential for accurate protein synthesis. Each …
correct tRNA. The fidelity of this reaction is essential for accurate protein synthesis. Each …
Crystal structures at 2.5 angstrom resolution of seryl-tRNA synthetase complexed with two analogs of seryl adenylate
…, C Berthet-Colominas, R Leberman, B Beijer, B Sproat… - Science, 1994 - science.org
Crystal structures of seryl-tRNA synthetase from Thermus thermophilus complexed with two
different analogs of seryl adenylate have been determined at 2.5 Å resolution. The first …
different analogs of seryl adenylate have been determined at 2.5 Å resolution. The first …
Vancomycin resistance is overcome by conjugation of polycationic peptides
…, C Kleist, S Zimmermann, B Beijer… - Angewandte Chemie …, 2020 - Wiley Online Library
… in MIC values in blocking experiments (Figure 1 B). Besides, a high antimicrobial potential is
not … B) The in vivo activity of FU002 could be confirmed by a significant reduction of bacterial …
not … B) The in vivo activity of FU002 could be confirmed by a significant reduction of bacterial …
Renal targeting: peptide-based drug delivery to proximal tubule cells
…, D Sarko, M Janzer, C Kaufman, B Beijer… - Bioconjugate …, 2016 - ACS Publications
… The microscans B and D demonstrate a general view of the localization of the FITC-labeled
DOTA-εPLL in the renal cortex. C. Control: kidney of a NMRI-mouse injected with 0.9% NaCl. …
DOTA-εPLL in the renal cortex. C. Control: kidney of a NMRI-mouse injected with 0.9% NaCl. …
The synthesis of protected 5′-mercapto-2′, 5′-dideoxyribonucleoside-3′-0-phosphorainidites; uses of 5′-mercapto-oligodeoxyribonucleotides
BS Sproat, B Beijer, P Rider, P Neuner - Nucleic acids research, 1987 - academic.oup.com
… , Connolly and Rider reported the synthesis of 5'-mercaptoalkyl phospho-oligodeoxyribonucleotides
(1), however the alkyl spacer has to be at least 3 C atoms long (Connolly, B. …
(1), however the alkyl spacer has to be at least 3 C atoms long (Connolly, B. …
Development of novel PSMA ligands for imaging and therapy with copper isotopes
JC Dos Santos, B Beijer, U Bauder-Wüst… - Journal of Nuclear …, 2020 - Soc Nuclear Med
Prostate-specific membrane antigen (PSMA)–binding tracers have been shown to be
promising agents for the specific targeting of prostate tumors. On labeling with the short-lived …
promising agents for the specific targeting of prostate tumors. On labeling with the short-lived …
Radiopharmaceutical therapy of patients with metastasized melanoma with the melanin-binding benzamide 131I-BA52
…, JC Hassel, FL Giesel, B Beijer… - Journal of Nuclear …, 2014 - Soc Nuclear Med
The performance of cytotoxic drugs is defined by their selectivity of uptake and action in
tumor tissue. Recent clinical responses achieved by treating metastatic malignant melanoma …
tumor tissue. Recent clinical responses achieved by treating metastatic malignant melanoma …