A novel adenylyl cyclase-activating serotonin receptor (5-HT7) implicated in the regulation of mammalian circadian rhythms
…, MA Rea, PE Foye, M Racke, AL Slone, BW Siegel… - Neuron, 1993 - cell.com
We report the cloning and characterization of a novel serotonin receptor, designated as 5-HT,,
which is coupled to the stimulation of adenylyl cyclase. 5-HT7 mRNA is expressed …
which is coupled to the stimulation of adenylyl cyclase. 5-HT7 mRNA is expressed …
Preclinical characterization of the potential of the putative atypical antipsychotic MDL 100,907 as a potent 5-HT2A antagonist with a favorable CNS safety profile.
…, DR McCarty, M Poirot, Y Senyah, BW Siegel… - … of Pharmacology and …, 1996 - ASPET
In preclinical studies, [R-(+)-alpha-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-
piperidinemethanol] [formula: see text] (MDL 100,907), a putative atypical antipsychotic, was …
piperidinemethanol] [formula: see text] (MDL 100,907), a putative atypical antipsychotic, was …
Two members of a distinct subfamily of 5-hydroxytryptamine receptors differentially expressed in rat brain.
…, M Racke, AL Slone, BW Siegel… - Proceedings of the …, 1993 - National Acad Sciences
We report two serotonin (5-hydroxytryptamine, 5-HT) receptors, MR22 and REC17, that
belong to the G-protein-associated receptor superfamily. MR22 and REC17 are 371 and 357 …
belong to the G-protein-associated receptor superfamily. MR22 and REC17 are 371 and 357 …
Molecular cloning and functional expression of 5-HT1E-like rat and human 5-hydroxytryptamine receptor genes.
…, M Racke, AL Slone, BW Siegel… - Proceedings of the …, 1993 - National Acad Sciences
… cAMP accumulation was measured by a method similar to that described by Baron and Siegel
(21). HeLa cells were transfected by the … & Siegel, BW (1989) J. Neurochem. 53, 602609. …
(21). HeLa cells were transfected by the … & Siegel, BW (1989) J. Neurochem. 53, 602609. …
Cilia regeneration in the sea urchin embryo: evidence for a pool of ciliary proteins
W Auclair, BW Siegel - Science, 1966 - science.org
Late gastrulae of Paracentrotus lividus regenerated cilia after being deciliated in hypertonic
sea water. Regeneration was not affected by actinomycin D or puromycin. Actinomycin D …
sea water. Regeneration was not affected by actinomycin D or puromycin. Actinomycin D …
[3H]MDL 100,907: a novel selective 5-HT2A receptor ligand
MP Johnson, BW Siegel, AA Carr - Naunyn-Schmiedeberg's archives of …, 1996 - Springer
In studies using standard radioligands, unlabeled MDL 100,907 (R-(+)-α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol)
has been shown to have a high …
has been shown to have a high …
Rapid down regulation of β-adrenoceptors by co-administration of desipramine and fluoxetine
BM Baron, AM Ogden, BW Siegel, J Stegeman… - European Journal of …, 1988 - Elsevier
Co-administration of desipramine and fluoxetine resulted in a 27% decline in cerebral cortical
β-adrenoceptor density after four days — a time point at which neither agent alone was …
β-adrenoceptor density after four days — a time point at which neither agent alone was …
[3H] MDL 105,519, a high-affinity radioligand for the N-methyl-D-aspartate receptor-associated glycine recognition site.
BM Baron, BW Siegel, BL Harrison, RS Gross… - … of Pharmacology and …, 1996 - ASPET
MDL 105,519 [(E)-3-(2-phenyl-2-carboxyethenyl)-4, 6-dichloro-1H-indole-2-carboxylic acid]
is a potent ligand at the N-methyl-D-aspartate (NMDA) receptor-associated glycine …
is a potent ligand at the N-methyl-D-aspartate (NMDA) receptor-associated glycine …
Characterization of the novel 5-HT3 antagonists MDL 73147EF (dolasetron mesilate) and MDL 74156 in NG108-15 neuroblastoma× glioma cells
…, M Galvan, BM Baron, MW Dudley, BW Siegel… - European journal of …, 1992 - Elsevier
In radioligand binding experiments, MDL 73147EF and MDL 74156 inhibited the binding of
[ 3 H]GR65630 to 5-hydroxytryptamine 3 (5-HT 3 ) binding sites on membranes prepared …
[ 3 H]GR65630 to 5-hydroxytryptamine 3 (5-HT 3 ) binding sites on membranes prepared …
Potent indole-and quinoline-containing N-methyl-D-aspartate antagonists acting at the strychnine-insensitive glycine binding site.
…, MG Palfreyman, FG Salituro, BW Siegel… - … of Pharmacology and …, 1992 - ASPET
The N-methyl-D-aspartate (NMDA)-preferring glutamate receptor subtype possesses, in
addition to the recognition site for glutamate, a binding site for glycine. We report here on the …
addition to the recognition site for glutamate, a binding site for glycine. We report here on the …