Several macrolides have been reported to cause QT prolongation and ventricular arrhythmias
such as torsades de pointes. To clarify the underlying ionic mechanisms, we examined the …

A variety of drugs has been reported to cause acquired long QT syndrome through inhibition
of the I Kr channel. Screening compounds in early discovery and development stages …

Background— Therapeutic angiogenesis is a new approach to treating ischemic heart
disease, and the optimal method for assessing its efficacy is unclear. We used myocardial …

Delivery of gene therapy to inhibit intimal hyperplasia has been proposed to prevent
postangioplasty restenosis. We sought to apply gene therapy by using a stent-based technique. …

Drug-induced QT interval prolongation, ventricular arrhythmia and sudden death are one of
the leading causes for drug withdrawal from the market or denied regulatory approval. …

In cardiac muscle, sustained inward Na+ currents, also known as late Na+ currents (INa-L),
occur under physiological conditions during the cardiac Action Potential AP (AP). In addition …