Converging lines of evidence implicate the beta‐amyloid peptide (Aβ) as causative in
Alzheimer's disease. We describe a novel class of compounds that reduce Aβ production by …

Passive immunization with an antibody directed against the N terminus of amyloid β (Aβ)
has recently been reported to exacerbate cerebral amyloid angiopathy (CAA)-related …

Neurodegenerative processes in Alzheimer disease (AD) are thought to be driven in part by
the deposition of amyloid beta (A beta), a 39- to 43-amino acid peptide product resulting …

Human synovial fibroblast cell lines (HSN), established from tissues obtained from the knee
joints of arthritis patients undergoing arthoplasty, were used to investigate the effects of …

βA4 peptide (βAP) accumulates in amyloid plaques of Alzheimer's disease and may contribute
to neuronal degeneration. Conflicting observations have been reported regarding the …

Neurodegenerative processes in Alzheimer's disease (AD) are thought to be driven, in part,
by the deposition of amyloid beta (Aβ), a 39‐43‐aminoacid peptide product resulting from an …

Parathyroid hormone (PTH) and glycogen synthase kinase‐3 (GSK‐3) inhibitor 603281‐31‐8,
administered once daily increased bone formation in vivo. We investigated the molecular …

Neuropeptide Y (NPY) was originally isolated from extracts of porcine brain and is named
for the presence of an N-terminal tyrosine (tyr)“Y”) and a C-terminal tyrosine amide. NPY is a …

Functional NK-1 (substance P) receptors have been demonstrated previously on astrocyted
from primary newborn rat brain cultures and human astrocytoma cells lines by specific [ 125 I]…

Lanepitant is effective in the formalin analgesic model suggesting efficacy in painful neuropathy.
This study was designed to evaluate the dose-response effect of lanepitant in patients …