… The inoculation volume (0.2 ml) comprised a 50:50 mixture of cells in growth media and
Matrigel (BD Biosciences). Electronic calipers were used to measure the length and width of …

A highly potent and selective DGAT-1 inhibitor was identified and used in rodent models of
obesity and postprandial chylomicron excursion to validate DGAT-1 inhibition as a novel …

Endothelins(ET) are potent vasoactive peptides implicated in the pathogenesis of a number
of vascular diseases. The effects of ET on mammalian organs and cells are initiated by …

Recombinant human immunodeficiency virus 1 (HIV-1) protease, purified from a bacterial
expression system, processed a recombinant form of its natural substrate, Pr55gag, into …

Oligopeptides containing the consensus retroviral protease cleavage sequence Ser/Thr-XY-Tyr/Phe-Pro
are substrates for purified recombinant HIV-1 protease with K m 's in the …

Tactile allodynia, the enhanced perception of pain in response to normally non-painful
stimulation, represents a common complication of diabetic neuropathy. The activation of …

CC-1065 (NSC 298223), a potent new antitumor antibiotic produced by Streptomyces
zelensis, interacts strongly with double-stranded DNA and appears to exert its cytotoxic effects …

CC-1065, a novel antibiotic produced by Streptomyces zelensis, was active against several
experimental tumors in vivo and a broad spectrum of human tumor cells in vitro. This report …

Endothelins (ETs), 21-amino-acid peptides involved in the pathogenesis of various diseases,
bind to ET A and ET B receptors to initiate their effects. Based on the same core structure, …

Evaluation of multiple structurally distinct series of melanin concentrating hormone receptor
1 antagonists in an anesthetized rat cardiovascualar assay led to the identification of a …