Reactive oxygen species (ROS) and compromised antioxidant defense may contribute to
brain disorders such as stroke, amyotrophic lateral sclerosis, etc. Nitroxides are redox-sensitive …

Synthetic cathinones are common constituents of abused “bath salts” preparations and
represent a large family of structurally related compounds that function as cocaine-like inhibitors …

Background & Aims Disruption to endoplasmic reticulum (ER) calcium homeostasis has been
implicated in obesity, however, the ability to longitudinally monitor ER calcium fluctuations …

It is known fact that diabetes mellitus (DM) affects blood cells. Changes in the erythrocyte
membrane, disorder in hemoglobin oxygen-binding and modification in mechanical …

“Bath salts” preparations contain synthetic cathinones which interact with monoamine
transporters and function as either monoamine uptake inhibitors or releasers. 3,4-…

Active immunization is an emerging potential modality to combat fatal overdose amid the
opioid epidemic. In this study, we described the design, synthesis, formulation, and animal …

Ghrelin is a peptide that is produced by endocrine cells that are primarily localized in the
stomach. Ghrelin receptors (GHSR) are expressed in the brain and periphery. Preclinical and …

2,5-Dimethoxyphenethylamines (2C compounds) are 5-HT 2A/2C receptor agonists that
induce hallucinogenic effects. N-methoxybenzylation of 2C compounds markedly increases …

Opioid use disorders and fatal overdose due to consumption of fentanyl-laced heroin remain
a major public health menace in the United States. Vaccination may serve as a promising …

An improved synthesis of a haptenic heroin surrogate 1 (6-AmHap) is reported. The
intermediate needed for the preparation of 1 was described in the route in the synthesis of 2 (…