With the recent approval by the Food and Drug Administration (FDA) of Deep Brain
Stimulation (DBS) for Parkinson’s Disease, dystonia and obsessive compulsive disorder (OCD), …

With aging, abnormal benign growth of the prostate results in benign prostate hyperplasia (BPH)
with concomitant lower urinary tract symptoms (LUTS). Because the prostate is an …

Programmed death–ligand 1 (PD-L1) expression on tumor cells is essential for T cell impairment,
and PD-L1 blockade therapy has shown unprecedented durable responses in several …

The aim of the present work was to perform a systematic review of drug metabolism, transport,
pharmacokinetics, and DDI data available in the NDAs approved by the FDA in 2013, …

Emerging evidence suggests that crosstalk between glioma cells and the brain microenvironment
may influence brain tumor growth. To date, known reciprocal interactions among these …

Malignant tumors are considered “unresectable” if they are adhere to vital structures or the
surgery would cause irreversible damages to the patients. Though a variety of cytotoxic drugs …

During short-lived perturbations, such as inflammation, the gut microbiota exhibits resilience
and reverts to its original configuration. Although microbial access to the micronutrient iron …

The precise manipulation of microcirculation in mice can facilitate mechanistic studies of
brain injury and repair after ischemia, but this manipulation remains a technical challenge, …

Purpose: Immune checkpoint inhibitors (ICI) targeting the programmed cell death protein 1
and its ligand (PD-1/PD-L1) have transformed the treatment paradigm for metastatic renal cell …

PD-L1 detection using 89Zr-atezolizumab immuno-PET in renal cell carcinoma tumorgrafts
from a patient with favorable nivolumab response | Journal for ImmunoTherapy of Cancer …