The brain noradrenergic system is activated by acute stress. The post-synaptic effects of
norepinephrine (NE), exerted at a cellular or neural circuit level, have been described as …

Background The original RE-LY (Randomized Evaluation of Long-term Anticoagulant
Therapy) trial suggested a small increased risk of myocardial infarction (MI) with the use of …

■ ABSTRACT Nowadays, doctors face an overwhelming amount of information, even in
narrow areas of interest. In response, reviews designed to summarize the large volumes of …

ERA‐40 is a re‐analysis of meteorological observations from September 1957 to August
2002 produced by the European Centre for Medium‐Range Weather Forecasts (ECMWF) in …

Background Sodium–glucose cotransporter 2 (SGLT2) inhibitors reduce the risk of hospitalization
for heart failure and cardiovascular death among patients with chronic heart failure …

Background The estimated number of new HIV infections in the United States reflects the
leading edge of the epidemic. Previously, CDC estimated HIV incidence in the United States in …

Background Loop diuretics are an essential component of therapy for patients with acute
decompensated heart failure, but there are few prospective data to guide their use. Methods In …

Background The cardiovascular effects of adding once-weekly treatment with exenatide to
usual care in patients with type 2 diabetes are unknown. Methods We randomly assigned …

Background Both balanced crystalloids and saline are used for intravenous fluid administration
in critically ill adults, but it is not known which results in better clinical outcomes. Methods …

Background Nesiritide is approved in the United States for early relief of dyspnea in patients
with acute heart failure. Previous meta-analyses have raised questions regarding renal …