The cellular influx and efflux of thyroid hormones are facilitated by transmembrane protein
transporters. Of these transporters, monocarboxylate transporter 8 (MCT8) is the only one …

The purpose of this review is to provide an up-to-date report on the molecular and
physiologic processes involved in the role of thyroid hormone as an epigenetic factor in brain …

Thyroid hormone plays an essential role in mammalian brain maturation and function, in
large part by regulating the expression of specific neuronal genes. In this tissue, the type 2 …

Hormonal imbalances are involved in many of the age-related pathologies, as neurodegenerative
and psychiatric diseases. Specifically, thyroid state alterations in the adult are related …

Context: Mutations in the MCT8 (SLC16A2) gene, encoding a specific thyroid hormone
transporter, cause an X-linked disease with profound psychomotor retardation, neurological …

The transcriptional properties of unliganded thyroid hormone receptors are thought to cause
the misdevelopment during hypothyroidism of several functions essential for adult life. To …

Allan-Herndon-Dudley syndrome is a rare disease caused by inactivating mutations in the
SLC16A2 gene, which encodes the monocarboxylate transporter 8 (MCT8), a transmembrane …

Thyroid hormone is an important epigenetic factor in brain development, acting by modulating
rates of gene expression. The active form of thyroid hormone, 3,5,3′-triiodothyronine (T3) …

Activity‐dependent changes taking place at the hippocampal perforant pathway–dentate gyrus
synapse during classical eyeblink conditioning were recorded in adult thyroidectomized (…

Thyroid hormones (TH) are crucial for brain development; their deficiency during neurodevelopment
impairs neural cell differentiation and causes irreversible neurological alterations. …