User profiles for A. Eldefrawi

Ahmed Eldefrawy, MD

Miami Cancer Institute, Florida International University
Verified email at baptisthealth.net
Cited by 1186

Common mechanism of toxicity: a case study of organophosphorus pesticides

…, W Dettbarn, M Ehrich, AT Eldefrawi… - Toxicological …, 1998 - academic.oup.com
The Food Quality Protection Act of 1996 (FQPA) requires the EPA to consider “available
information concerning the cumulative effects of such residues and other substances that have a …

Direct actions of organophosphate anticholinesterases on nicotinic and muscarinic acetylcholine receptors

…, AT Eldefrawi, ME Eldefrawi - Journal of …, 1988 - Wiley Online Library
Four nerve agents and one therapeutic organophosphate (OP) anticholinesterase (anti‐ChE)
bind to acetylcholine (ACh) receptors, inhibit or modulate binding of radioactive ligands to …

Receptors for γ‐aminobutyric acid and voltage‐dependent chloride channels as targets for drugs and toxicants1

AT Eldefrawi, ME Eldefrawi - The FASEB journal, 1987 - Wiley Online Library
The function of chloride (Cl − ) channel proteins is to regulate the transport of Cl − across
membranes. There are two major kinds of Cl − channels: 1) those activated by binding of a …

Structure and synthesis of a potent glutamate receptor antagonist in wasp venom.

AT Eldefrawi, ME Eldefrawi, K Konno… - Proceedings of the …, 1988 - National Acad Sciences
A low molecular weight toxin isolated from the venom of the digger wasp Philanthus
triangulum, first noted by T. Piek, is a potent antagonist of transmission at quisqualate-sensitive …

Careful selection and close monitoring of low-risk prostate cancer patients on active surveillance minimizes the need for treatment

MS Soloway, CT Soloway, A Eldefrawy, K Acosta… - European urology, 2010 - Elsevier
BACKGROUND: With the advent of prostate-specific antigen (PSA) screening and the increase
in the number of transrectal ultrasound–guided biopsy cores, there has been a dramatic …

Design, synthesis and pharmacological profile of novel dopamine D2 receptor ligands

…, EFR Perreira, A El-Nabawi, AT Eldefrawi… - Bioorganic & medicinal …, 2003 - Elsevier
The present study describes the synthesis and pharmacological profile of three novel
heterocyclic compounds originally designed, on the basis of bioisosterism, as dopamine D2 …

Systemic therapy in the management of localized and locally advanced renal cell carcinoma: current state and future perspectives

…, K Yim, ST Ryan, SH Patel, A Eldefrawy… - … Journal of Urology, 2019 - Wiley Online Library
Systemic therapy strategies in the setting of localized and locally advanced renal cell carcinoma
have continued to evolve in two directions: (i) as adjuvant therapy (to reduce the risk of …

Effects of insecticides on GABA‐induced chloride influx into rat brain microsacs

…, ME Eldefrawi, AT Eldefrawi - Journal of Toxicology and …, 1986 - Taylor & Francis
The actions of different insecticides known to affect binding of ligands to y‐amino‐butyric
acid (GABA) receptors were studied on the function of GABA A receptors in rat brain as …

Cyclodiene insecticides inhibit GABAA receptor-regulated chloride transport

DB Gant, ME Eldefrawi, AT Eldefrawi - Toxicology and applied …, 1987 - Elsevier
The function of GABA A receptors in rat brain was assayed by GABA stimulation of 36 Cl −
influx into membrane microsacs. The evidence that the measured flux resulted from GABA Aa …

Chlorpyrifos, parathion, and their oxons bind to and desensitize a nicotinic acetylcholine receptor: relevance to their toxicities

…, VI Cortes, ME Eldefrawi, AT Eldefrawi - Toxicology and applied …, 1997 - Elsevier
The nicotinic acetylcholine receptor (nAChR) of the electric organ of the electric ray.Torpedosp.,
the richest source of nAChR, with similar structure and pharmacology to the mammalian …