User profiles for A. D’Alessio

Ana D'Alessio

- Verified email at cellinobio.com - Cited by 20918

Antonio D'Alessio

- Verified email at imperial.ac.uk - Cited by 1749

The RAS/RAF/MEK/ERK and the PI3K/AKT signalling pathways: role in cancer pathogenesis and implications for therapeutic approaches

A De Luca, MR Maiello, A D'Alessio… - Expert opinion on …, 2012 - Taylor & Francis
Introduction: The RAS/RAF/MAP kinase–ERK kinase (MEK)/extracellular-signal-regulated
kinase (ERK) (MAPK) and the PI3K/AKT/mammalian target of rapamycin (mTOR) (PI3K) …

Management of hyperglycemia in type 2 diabetes, 2018. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study …

MJ Davies, DA D'Alessio, J Fradkin, WN Kernan… - Diabetes …, 2018 - Am Diabetes Assoc
The American Diabetes Association and the European Association for the Study of Diabetes
convened a panel to update the prior position statements, published in 2012 and 2015, on …

Central control of body weight and appetite

SC Woods, DA D'Alessio - The Journal of Clinical Endocrinology …, 2008 - academic.oup.com
Context Energy balance is critical for survival and health, and control of food intake is an
integral part of this process. This report reviews hormonal signals that influence food intake and …

Epigenetic programming by maternal behavior

…, N Cervoni, FA Champagne, AC D'Alessio… - Nature …, 2004 - nature.com
Here we report that increased pup licking and grooming (LG) and arched-back nursing (ABN)
by rat mothers altered the offspring epigenome at a glucocorticoid receptor (GR) gene …

Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse

PO McGowan, A Sasaki, AC D'alessio, S Dymov… - Nature …, 2009 - nature.com
Maternal care influences hypothalamic-pituitary-adrenal (HPA) function in the rat through
epigenetic programming of glucocorticoid receptor expression. In humans, childhood abuse …

[HTML][HTML] NASH limits anti-tumour surveillance in immunotherapy-treated HCC

…, E Bugianesi, V Ratziu, T Pressiani, A D'alessio… - Nature, 2021 - nature.com
Hepatocellular carcinoma (HCC) can have viral or non-viral causes 1 , 2 , 3 , 4 – 5 . Non-alcoholic
steatohepatitis (NASH) is an important driver of HCC. Immunotherapy has been …

Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification

S Ito, AC D'Alessio, OV Taranova, K Hong, LC Sowers… - Nature, 2010 - nature.com
DNA methylation is one of the best-characterized epigenetic modifications 1 , 2 , 3 , 4 .
Although the enzymes that catalyse DNA methylation have been characterized, enzymes …

[HTML][HTML] Systematic identification of culture conditions for induction and maintenance of naive human pluripotency

…, Y Stelzer, S Rangarajan, A D'Alessio… - Cell stem cell, 2014 - cell.com
Embryonic stem cells (ESCs) of mice and humans have distinct molecular and biological
characteristics, raising the question of whether an earlier, "naive" state of pluripotency may exist …

Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27Kip1 by PKB/Akt-mediated phosphorylation in breast cancer

…, P Bruni, RM Melillo, A D'alessio, D Califano… - Nature medicine, 2002 - nature.com
The cyclin-dependent kinase inhibitor p27 kip1 is a putative tumor suppressor for human
cancer. The mechanism underlying p27 kip1 deregulation in human cancer is, however, poorly …

[HTML][HTML] Poised chromatin at the ZEB1 promoter enables breast cancer cell plasticity and enhances tumorigenicity

…, T Lee, G Bell, CG Kleer, F Reinhardt, AC D'Alessio… - cell, 2013 - cell.com
The recent discovery that normal and neoplastic epithelial cells re-enter the stem cell state
raised the intriguing possibility that the aggressiveness of carcinomas derives not from their …