[HTML][HTML] Pathophysiology and therapeutics of thoracic aortic aneurysm in Marfan syndrome
K Asano, A Cantalupo, L Sedes, F Ramirez - Biomolecules, 2022 - mdpi.com
About 20% of individuals afflicted with thoracic aortic disease have single-gene mutations
that predispose the vessel to aneurysm formation and/or acute aortic dissection often without …
that predispose the vessel to aneurysm formation and/or acute aortic dissection often without …
S1P signaling and de novo biosynthesis in blood pressure homeostasis
A Cantalupo, A Di Lorenzo - Journal of Pharmacology and Experimental …, 2016 - ASPET
Initially discovered as abundant components of eukaryotic cell membranes, sphingolipids
are now recognized as important bioactive signaling molecules that modulate a variety of …
are now recognized as important bioactive signaling molecules that modulate a variety of …
[HTML][HTML] cGMP-dependent protein kinase contributes to hydrogen sulfide-stimulated vasorelaxation
…, Z Zhou, A Zaid, P Giannogonas, A Cantalupo… - PloS one, 2012 - journals.plos.org
A growing body of evidence suggests that hydrogen sulfide (H 2 S) is a signaling molecule
in mammalian cells. In the cardiovascular system, H 2 S enhances vasodilation and …
in mammalian cells. In the cardiovascular system, H 2 S enhances vasodilation and …
An engineered S1P chaperone attenuates hypertension and ischemic injury
Endothelial dysfunction, a hallmark of vascular disease, is restored by plasma high-density
lipoprotein (HDL). However, a generalized increase in HDL abundance is not beneficial, …
lipoprotein (HDL). However, a generalized increase in HDL abundance is not beneficial, …
Hydrogen sulfide accounts for the peripheral vascular effects of zofenopril independently of ACE inhibition
M Bucci, V Vellecco, A Cantalupo… - Cardiovascular …, 2014 - academic.oup.com
Aims Therapeutic use of sulfhydrylated inhibitor S-zofenopril has raised different hypotheses
regarding the role played by its thiol group in the beneficial clinical effects exerted …
regarding the role played by its thiol group in the beneficial clinical effects exerted …
S1PR1 (sphingosine-1-phosphate receptor 1) signaling regulates blood flow and pressure
A Cantalupo, A Gargiulo, E Dautaj, C Liu, Y Zhang… - …, 2017 - Am Heart Assoc
Nitric oxide is one of the major endothelial-derived vasoactive factors that regulate blood
pressure (BP), and the bioactive lipid mediator S1P (sphingosine-1-phosphate) is a potent …
pressure (BP), and the bioactive lipid mediator S1P (sphingosine-1-phosphate) is a potent …
Nogo-B regulates endothelial sphingolipid homeostasis to control vascular function and blood pressure
Endothelial dysfunction is a critical factor in many cardiovascular diseases, including
hypertension. Although lipid signaling has been implicated in endothelial dysfunction and …
hypertension. Although lipid signaling has been implicated in endothelial dysfunction and …
[HTML][HTML] The multiple functions of fibrillin-1 microfibrils in organismal physiology
K Asano, A Cantalupo, L Sedes, F Ramirez - International Journal of …, 2022 - mdpi.com
Fibrillin-1 is the major structural component of the 10 nm-diameter microfibrils that confer key
physical and mechanical properties to virtually every tissue, alone and together with elastin …
physical and mechanical properties to virtually every tissue, alone and together with elastin …
[HTML][HTML] Endothelial Nogo-B regulates sphingolipid biosynthesis to promote pathological cardiac hypertrophy during chronic pressure overload
Y Zhang, Y Huang, A Cantalupo, PS Azevedo… - JCI insight, 2016 - ncbi.nlm.nih.gov
We recently discovered that endothelial Nogo-B, a membrane protein of the ER, regulates
vascular function by inhibiting the rate-limiting enzyme, serine palmitoyltransferase (SPT), in …
vascular function by inhibiting the rate-limiting enzyme, serine palmitoyltransferase (SPT), in …
[HTML][HTML] Dissecting aortic aneurysm in Marfan syndrome is associated with losartan-sensitive transcriptomic modulation of aortic cells
To improve our limited understanding of the pathogenesis of thoracic aortic aneurysm (TAA)
that leads to acute aortic dissection, single-cell RNA sequencing (scRNA-seq) was …
that leads to acute aortic dissection, single-cell RNA sequencing (scRNA-seq) was …