[HTML][HTML] Pathophysiology and therapeutics of thoracic aortic aneurysm in Marfan syndrome

K Asano, A Cantalupo, L Sedes, F Ramirez - Biomolecules, 2022 - mdpi.com
About 20% of individuals afflicted with thoracic aortic disease have single-gene mutations
that predispose the vessel to aneurysm formation and/or acute aortic dissection often without …

S1P signaling and de novo biosynthesis in blood pressure homeostasis

A Cantalupo, A Di Lorenzo - Journal of Pharmacology and Experimental …, 2016 - ASPET
Initially discovered as abundant components of eukaryotic cell membranes, sphingolipids
are now recognized as important bioactive signaling molecules that modulate a variety of …

[HTML][HTML] cGMP-dependent protein kinase contributes to hydrogen sulfide-stimulated vasorelaxation

…, Z Zhou, A Zaid, P Giannogonas, A Cantalupo… - PloS one, 2012 - journals.plos.org
A growing body of evidence suggests that hydrogen sulfide (H 2 S) is a signaling molecule
in mammalian cells. In the cardiovascular system, H 2 S enhances vasodilation and …

An engineered S1P chaperone attenuates hypertension and ischemic injury

SL Swendeman, Y Xiong, A Cantalupo, H Yuan… - Science …, 2017 - science.org
Endothelial dysfunction, a hallmark of vascular disease, is restored by plasma high-density
lipoprotein (HDL). However, a generalized increase in HDL abundance is not beneficial, …

Hydrogen sulfide accounts for the peripheral vascular effects of zofenopril independently of ACE inhibition

M Bucci, V Vellecco, A Cantalupo… - Cardiovascular …, 2014 - academic.oup.com
Aims Therapeutic use of sulfhydrylated inhibitor S-zofenopril has raised different hypotheses
regarding the role played by its thiol group in the beneficial clinical effects exerted …

S1PR1 (sphingosine-1-phosphate receptor 1) signaling regulates blood flow and pressure

A Cantalupo, A Gargiulo, E Dautaj, C Liu, Y Zhang… - …, 2017 - Am Heart Assoc
Nitric oxide is one of the major endothelial-derived vasoactive factors that regulate blood
pressure (BP), and the bioactive lipid mediator S1P (sphingosine-1-phosphate) is a potent …

Nogo-B regulates endothelial sphingolipid homeostasis to control vascular function and blood pressure

A Cantalupo, Y Zhang, M Kothiya, S Galvani… - Nature medicine, 2015 - nature.com
Endothelial dysfunction is a critical factor in many cardiovascular diseases, including
hypertension. Although lipid signaling has been implicated in endothelial dysfunction and …

[HTML][HTML] The multiple functions of fibrillin-1 microfibrils in organismal physiology

K Asano, A Cantalupo, L Sedes, F Ramirez - International Journal of …, 2022 - mdpi.com
Fibrillin-1 is the major structural component of the 10 nm-diameter microfibrils that confer key
physical and mechanical properties to virtually every tissue, alone and together with elastin …

[HTML][HTML] Endothelial Nogo-B regulates sphingolipid biosynthesis to promote pathological cardiac hypertrophy during chronic pressure overload

Y Zhang, Y Huang, A Cantalupo, PS Azevedo… - JCI insight, 2016 - ncbi.nlm.nih.gov
We recently discovered that endothelial Nogo-B, a membrane protein of the ER, regulates
vascular function by inhibiting the rate-limiting enzyme, serine palmitoyltransferase (SPT), in …

[HTML][HTML] Dissecting aortic aneurysm in Marfan syndrome is associated with losartan-sensitive transcriptomic modulation of aortic cells

Y Sun, K Asano, L Sedes, A Cantalupo, J Hansen… - JCI insight, 2023 - ncbi.nlm.nih.gov
To improve our limited understanding of the pathogenesis of thoracic aortic aneurysm (TAA)
that leads to acute aortic dissection, single-cell RNA sequencing (scRNA-seq) was …