Many candidate biomarkers of human ageing have been proposed in the scientific literature
but in all cases their variability in cross-sectional studies is considerable, and therefore no …

A complex interplay between multiple biological effects shapes the aging process. The
advent of genome-wide quantitative approaches in the epigenetic field has highlighted the …

PrP C ‐deficient mice expressing prion protein variants with large amino‐proximal deletions
(termed PrP ΔF ) suffer from neurodegeneration, which is rescued by full‐length PrP C . We …

Aims Imbalance between pro- and antioxidant species (eg during aging) plays a crucial role
for vascular function and is associated with oxidative gene regulation and modification. …

The recent clinical availability of the PARP inhibitor olaparib (Lynparza) opens the door for
potential therapeutic repurposing for non‐oncological indications. Considering (a) the …

Activation of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) is an early response
of cells exposed to DNA-damaging compounds such as nitric oxide (NO) or reactive oxygen …

Poly(ADP-ribosyl)ation (PARylation) is a posttranslational protein modification (PTM) catalyzed
by members of the poly(ADP-ribose) polymerase (PARP) enzyme family. PARPs use …

Ageing is highly complex, involving multiple mechanisms at different levels. Nevertheless,
recent evidence suggests that several of the most important mechanisms are linked via …

Self-rated health (SRH) is one of the most frequently used indicators in health and social
research. Its robust association with mortality in very different populations implies that it is a …

Poly(ADP-ribose) (PAR) is synthesized by poly(ADP-ribose) polymerases in response to
genotoxic stress and interacts non-covalently with DNA damage checkpoint and repair proteins. …