User profiles for A. Alt

Andrew Alt

Director, Center for Chemical Genomics, University of Michigan
Verified email at umich.edu
Cited by 2799

Glutamate receptors and pain

D Bleakman, A Alt, ES Nisenbaum - Seminars in cell & developmental …, 2006 - Elsevier
… the channel, a large extracellular region between TM3 and TM4 and a small intracellular
carboxy terminus. The agonist binding site for glutamate is on the GLU N2 subunits and there is …

AMPA receptors in the therapeutic management of depression

D Bleakman, A Alt, JM Witkin - CNS & Neurological Disorders …, 2007 - ingentaconnect.com
… are a rapid activation by glutamate (or AMPA) and a decay in the current due to a process
… Specifically, for GLUA2 editing within the pore forming region of TM2 of a glutamine (Q) to …

A role for AMPA receptors in mood disorders

A Alt, ES Nisenbaum, D Bleakman, JM Witkin - Biochemical pharmacology, 2006 - Elsevier
… hypothesis of depression remains a cornerstone of our … of glutamate receptor may also play
a pivotal role in depression. … is driven by neurogenesis, a process facilitated by increased …

Survival after complete surgical resection of multiple metastases from renal cell carcinoma

AL Alt, SA Boorjian, CM Lohse, BA Costello… - Cancer, 2011 - Wiley Online Library
a 5-year CSS rate of 73.6% with complete resection versus 19% without complete resection
(P < .001). A … multiple, nonlung-only metastases, who had a 5-year CSS rate of 32.5% with …

Iodine content of food groups

M Haldimann, A Alt, A Blanc, K Blondeau - Journal of food Composition …, 2005 - Elsevier
The iodine content of several kinds of foods representing different product groups available
on the Swiss market was analyzed by isotope dilution inductively coupled plasma mass …

An algorithm for optimal partitioning of data on an interval

…, JD Scargle, D Barnes, S Arabhi, A Alt… - IEEE Signal …, 2005 - ieeexplore.ieee.org
… We avoid a precise definition because many types of data … a segment to each data point.
In the Bayesian setting described above, a natural way to address this problem is to adopt a

Differential accumulation of advanced glycation end products in the course of diabetic retinopathy

HP Hammes, A Alt, T Niwa, JT Clausen, RG Bretzel… - Diabetologia, 1999 - Springer
Aims/hypothesis. Glycated proteins, formed by reaction of glucose and protein, react further
yielding numerous, mostly undefined advanced glycation end products (AGE). The recently …

Decomposition of triacetone triperoxide is an entropic explosion

…, J Almog, Y Zeiri, R Boese, H Itzhaky, A Alt… - Journal of the …, 2005 - ACS Publications
… of a computational study of the thermal decomposition pathways of 1, that the explosion of
this compound is not a … units play merely the role of a molecular scaffold that holds the three …

Bypass of DNA lesions generated during anticancer treatment with cisplatin by DNA polymerase η

A Alt, K Lammens, C Chiocchini, A Lammens, JC Pieck… - Science, 2007 - science.org
… fluorescein-labeled 13mer hybridized to an 18mer DNA template either with a site-specific …
(C), with a fluorescein-labeled 14mer hybridized to a 18mer DNA template with either a site …

Cancer chemopreventive activity of xanthohumol, a natural product derived from hop

C Gerhauser, A Alt, E Heiss, A Gamal-Eldeen… - Molecular cancer …, 2002 - AACR
a solvent control, and CD values were generated. β-NF was used as a positive control with a
… For IX, we determined a CD value of 6.5 ± 1.5 μm with a concomitant IC 50 of 29.9 ± 1.9 μm …