Characterisation of α2-adrenoceptor subtypes involved in gastric emptying, gastric motility and gastric mucosal defence

K Fülöp, Z Zádori, AZ Rónai, K Gyires - European journal of pharmacology, 2005 - Elsevier
The effect of clonidine on ethanol-induced gastric mucosal damage, gastric emptying and
gastric motility was compared. The clonidine-induced gastroprotective effect (0.03–0.09 μmol/…

Supraspinal δ-and μ-opioid receptors mediate gastric mucosal protection in the rat

K Gyires, AZ Ronai - Journal of Pharmacology and Experimental …, 2001 - ASPET
This study evaluated the contribution of supraspinal opioid receptors to gastric mucosal
protection in the rat. Intracerebroventricular (icv) and intracisternal (ic) injections of selective δ- {[d…

Alpha-2 adrenergic and opioid receptor-mediated gastroprotection

K Gyires, K Müllner, S Fürst, AZ Rónai - Journal of Physiology-Paris, 2000 - Elsevier
Clonidine inhibited the development of gastric mucosal lesions induced by either acidified
ethanol or indomethacin. The ED 50 values were: 7.1 and 5.2 μg.kg –1 orally, respectively. …

Comparative study on analgesic effect of Met5-enkephalin and related lipotropin fragments

L Graf, JI Szekely, AZ Ronai, Z Dunai-Kovács, S Bajusz - Nature, 1976 - nature.com
HUGHES et al. have reported the isolation and structure of two pentapeptides from porcine
brain with opiate agonist activity in isolated systems. The structure of one of these peptides, …

Structure− activity study on the Phe side chain arrangement of endomorphins using conformationally constrained analogues

…, A Borsodi, M Al-Khrasani, AZ Rónai… - Journal of medicinal …, 2004 - ACS Publications
Endomorphins-1 and -2 were substituted with all the β-MePhe stereoisomers in their Phe
residues to generate a conformationally constrained peptide set. This series of molecules was …

CD and Fourier transform IR spectroscopic studies of peptides. II. Detection of β‐turns in linear peptides

M Hollosi, ZS Majer, AZ Ronai, A Magyar… - Biopolymers …, 1994 - Wiley Online Library
Comparative CD and Fourier transform ir (FTIR) spectroscopic data on N‐Boc protected
linear peptides with or without the (Pro‐Gly) β‐turn motif (eg, Boc‐Tyr‐Pro‐Gly‐Phe‐Leu‐OH …

Receptor constants for endomorphin-1 and endomorphin-1-ol indicate differences in efficacy and receptor occupancy

…, I Lengyel, S Benyhe, A Borsodi, AZ Rónai - European journal of …, 2001 - Elsevier
The opioid properties of endomorphin derivatives containing a C-terminal alcoholic(-ol)
function were compared to the parent amidated compounds in isolated organs (longitudinal …

[PDF][PDF] A superactive antinociceptive pentapeptide,(D-Met2, Pro5)-enkephalinamide

S Bajusz, AZ Rónai, JI Székely, L Gráf, Z Dunai-Kovács… - Febs Lett, 1977 - core.ac.uk
Our recent study [1] on synthetic analogs of enkephalins (Tyr-Gly-Gly-Phe-X, X= Met and Leu
[2]) has revealed some structural requirements for a pentapeptide to exert antinociceptive …

Intracerebroventricular injection of clonidine releases β-endorphin to induce mucosal protection in the rat

K Gyires, AZ Rónai, K Müllner, S Fürst - Neuropharmacology, 2000 - Elsevier
The possibility that the endogenous opioid system could be involved in the central nervous
system (CNS)-mediated gastroprotective effect of clonidine was investigated. …

Angiotensin II-induced activation of central AT1 receptors exerts endocannabinoid-mediated gastroprotective effect in rats

K Gyires, AZ Rónai, ZS Zádori, VE Tóth… - Molecular and cellular …, 2014 - Elsevier
The aim of the present study was to analyze whether angiotensin II via the endocannabinoid
system can induce gastric mucosal protection, since transactivation of cannabinoid CB 1 …