Intrauterine or early postnatal high-fat diet (HFD) has substantial influences on adult offspring
health; however, studies of HFD-induced maternal obesity on regulation of adult offspring …

Buprenorphine is the preferred treatment of opioid use disorder during pregnancy but can
cause fetal opioid dependence and neonatal opioid withdrawal syndrome (NOWS). Notably, …

Background Chronic alcohol consumption leads to increased fracture risk and an elevated
risk of osteoporosis by decreasing bone accrual through increasing osteoclast activity and …

Phenolic acids (PAs) are metabolites derived from polyphenolic compounds found in fruits
and vegetables resulting from the actions of gut bacteria. Previously, we reported that the …

Many conventional genetic toxicology assays require specialized cell cultures or animals and
can only detect mutations that inactivate the function of a reporter gene. These limitations …

Chronic alcohol consumption increases bone resorption and decreases bone formation. A
major component of ethanol (EtOH) pathology in bone is the generation of excess reactive …

Skeletal toxicity has been reported following exposure to polychlorinated biphenyl (PCB)
mixtures. However, molecular mechanisms remain poorly understood. We exposed groups of …

In contrast to somatic mutations, mutations in germ cells affect every cell of any organism
derived from the germ cell and therefore are related to numerous genetic diseases. However, …

The increasing medical and food applications of silver nanoparticles (AgNPs) raise
concerns about their safety, including the potential health consequences of human exposure. …

Chronic ethyl alcohol (EtOH) consumption results in reactive oxygen species (ROS) generation
in bone and osteopenia due to increased bone resorption and reduced bone formation. …