The GPR119 receptor plays an important role in the secretion of incretin hormones in
response to nutrient consumption. We have studied the ability of an array of naturally occurring …

… Competitive binding was either not significant or had a K i value of >10 μM at the following
receptor, ion channel, or enzyme targets: acetylcholinesterase, CCK1, CCK2, EDG-2, Cox1, …

We have reported that [methyl- 11 C] (3R,5R)-5-(3-methoxyphenyl)-3-[(R)-1-phenylethylamino]-1-(4-trifluoromethylphenyl)pyrrolidin-2-one
([ 11 C]8, [ 11 C]MePPEP) binds with high …

Alzheimer's disease and schizophrenia are characterized by expression of psychotic, affective,
and cognitive symptoms. Currently, there is a lack of adequate treatment for the cognitive …

The generation of muscarinic acetylcholine receptor (mAChR) subtype-selective compounds
has been challenging, requiring use of nonpharmacological approaches, such as …

Cannabinoids, in the form of marijuana plant extracts, have been used for thousands of years
for a wide variety of medical conditions, ranging from general malaise and mood disorders …

Phytocannabinoids, such as the principal bioactive component of marijuana, Δ 9 -tetrahydrocannabinol,
have been used for thousands of years for medical and recreational purposes. Δ …

Statistical parameters estimated in validation studies to establish the reliability of single‐concentration
assays, such as the Signal Window and Z'‐Factor, are well established. These …

… [ 3 H]MePPEP binding to human CB 1 /CHO membranes was best fit to a one-phase association
model and yielded a K on value of 1.8 × 10 8 (M − 1 , min − 1 ) (Fig. 3). The dissociation …

1. The mechanism of anandamide uptake and disposal has been an issue of considerable
debate in the cannabinoid field. Several compounds have been reported to inhibit …