Mechanisms of hepatotoxicity

H Jaeschke, GJ Gores, AI Cederbaum… - Toxicological …, 2002 - academic.oup.com
This review addresses recent advances in specific mechanisms of hepatotoxicity. Because
of its unique metabolism and relationship to the gastrointestinal tract, the liver is an important …

Alcohol metabolism

AI Cederbaum - Clinics in liver disease, 2012 - liver.theclinics.com
1. Learn how the body disposes of alcohol and its metabolites. 2. Discern some of the factors
that influence this process. 3. Learn how alcohol influences the metabolism of nutrients and …

[HTML][HTML] Alcohol, oxidative stress, and free radical damage

D Wu, AI Cederbaum - Alcohol research & health, 2003 - ncbi.nlm.nih.gov
Reactive oxygen species (ROS) are small, highly reactive, oxygen-containing molecules
that are naturally generated in small amounts during the body’s metabolic reactions and can …

CYP2E1 and oxidative liver injury by alcohol

Y Lu, AI Cederbaum - Free Radical Biology and Medicine, 2008 - Elsevier
Ethanol-induced oxidative stress seems to play a major role in mechanisms by which ethanol
causes liver injury. Many pathways have been suggested to contribute to the ability of …

Production of formaldehyde during metabolism of dimethyl sulfoxide by hydroxyl radical-generating systems

SM Klein, G Cohen, AI Cederbaum - Biochemistry, 1981 - ACS Publications
ABSTRACTZ Dimethyl sulfoxide is a potent hydroxyl radical scavenging agent. The production
of methane from dimethyl sulfoxide has been used to detect the generation of hydroxyl …

Role of oxidative stress in alcohol-induced liver injury

AI Cederbaum, Y Lu, D Wu - Archives of toxicology, 2009 - Springer
Reactive oxygen species (ROS) are highly reactive molecules that are naturally generated
in small amounts during the body’s metabolic reactions and can react with and damage …

Alcohol and oxidative liver injury

A Dey, AI Cederbaum - Hepatology, 2006 - journals.lww.com
Acute and chronic ethanol treatment has been shown to increase the production of reactive
oxygen species, lower cellular antioxidant levels, and enhance oxidative stress in many …

Oxidative stress, toxicology, and pharmacology of CYP2E1

AA Caro, AI Cederbaum - Annu. Rev. Pharmacol. Toxicol., 2004 - annualreviews.org
This review describes some of the biochemical and toxicological properties of CYP2E1,
especially as it relates to alcohol metabolism and toxicity and the establishment of human …

A high‐fat diet leads to the progression of non‐alcoholic fatty liver disease in obese rats

M Carmiel-Haggai, AI Cederbaum… - The FASEB …, 2005 - Wiley Online Library
Fatty livers of obese fa/fa rats are vulnerable to injury when challenged by insults such as
endotoxin, ischemia‐reperfusion or acute ethanol treatment. The objective of this study was to …

Oxidative stress and alcoholic liver disease

D Wu, AI Cederbaum - Seminars in liver disease, 2009 - thieme-connect.com
Reactive oxygen species (ROS) are highly reactive molecules that are naturally generated
in small amounts during the body's metabolic reactions and can react with and damage …