Identification and synthesis of novel alkaloids from the root system of Nicotiana tabacum: Affinity for neuronal nicotinic acetylcholine receptors
X Wei, SP Sumithran, AG Deaciuc, HR Burton, LP Bush… - Life Sciences, 2005 - Elsevier
A novel pyridine derivative, 3,5-bis-(1-methyl-pyrrolidin-2-yl)-pyridine, and a pair of diastereomers
of 1,1′-dimethyl-[2,3′]bipyrrolidinyl were isolated from the root of Nicotiana tabacum …
of 1,1′-dimethyl-[2,3′]bipyrrolidinyl were isolated from the root of Nicotiana tabacum …
Defunctionalized Lobeline Analogues: Structure− Activity of Novel Ligands for the Vesicular Monoamine Transporter
G Zheng, LP Dwoskin, AG Deaciuc… - Journal of medicinal …, 2005 - ACS Publications
(−)-Lobeline (2R,6S,10S; 1a), an antagonist at nicotinic acetylcholine receptors (nAChRs),
inhibits the neurochemical and behavioral effects of methamphetamine and inhibits …
inhibits the neurochemical and behavioral effects of methamphetamine and inhibits …
bis-Azaaromatic quaternary ammonium analogues: ligands for α4β2* and α7* subtypes of neuronal nicotinic receptors
JT Ayers, LP Dwoskin, AG Deaciuc… - Bioorganic & medicinal …, 2002 - Elsevier
A series of bis-nicotinium, bis-pyridinium, bis-picolinium, bis-quinolinium and bis-isoquinolinium
compounds was evaluated for their binding affinity at nicotinic acetylcholine receptors (…
compounds was evaluated for their binding affinity at nicotinic acetylcholine receptors (…
Lobelane analogues as novel ligands for the vesicular monoamine transporter-2
G Zheng, LP Dwoskin, AG Deaciuc, J Zhu… - Bioorganic & medicinal …, 2005 - Elsevier
A series of lobelane analogues has been synthesized and their structure–activity relationships
at the vesicular monoamine transporter-2 (VMAT2) have been evaluated. The most potent …
at the vesicular monoamine transporter-2 (VMAT2) have been evaluated. The most potent …
Subtype-selective nicotinic receptor antagonists: potential as tobacco use cessation agents
LP Dwoskin, SP Sumithran, J Zhu, AG Deaciuc… - Bioorganic & medicinal …, 2004 - Elsevier
Nn-Alkylpicolinium and N,N′-alkyl-bis-picolinium analogues were assessed in nicotinic
receptor (nAChR) assays. The most potent and subtype-selective analogue, N,N′-dodecyl-bis-…
receptor (nAChR) assays. The most potent and subtype-selective analogue, N,N′-dodecyl-bis-…
Computational neural network analysis of the affinity of lobeline and tetrabenazine analogs for the vesicular monoamine transporter-2
Back-propagation artificial neural networks (ANNs) were trained on a dataset of 104 VMAT2
ligands with experimentally measured log(1/K i ) values. A set of related descriptors, …
ligands with experimentally measured log(1/K i ) values. A set of related descriptors, …
N, N′-Alkane-diyl-bis-3-picoliniums as nicotinic receptor antagonists: inhibition of nicotine-evoked dopamine release and hyperactivity
…, VK Manda, JT Ayers, Z Zhang, AG Deaciuc… - … of Pharmacology and …, 2008 - ASPET
The current study evaluated a new series of N,N′-alkane-diyl-bis-3-picolinium (bAPi) analogs
with C 6 –C 12 methylene linkers as nicotinic acetylcholine receptor (nAChR) antagonists…
with C 6 –C 12 methylene linkers as nicotinic acetylcholine receptor (nAChR) antagonists…
Tobacco's minor alkaloids: Effects on place conditioning and nucleus accumbens dopamine release in adult and adolescent rats
…, AG Wilson, ED Denehy, A Ebben, AG Deaciuc… - European journal of …, 2017 - Elsevier
Tobacco products are some of the most commonly used psychoactive drugs worldwide.
Besides nicotine, alkaloids in tobacco include cotinine, myosmine, and anatabine. Scientific …
Besides nicotine, alkaloids in tobacco include cotinine, myosmine, and anatabine. Scientific …
Synthesis and evaluation of a series of homologues of lobelane at the vesicular monoamine transporter-2
G Zheng, LP Dwoskin, AG Deaciuc… - Bioorganic & medicinal …, 2008 - Elsevier
A series of lobelane homologues has been synthesized and evaluated for their [ 3 H]DTBZ
binding affinity at the vesicular monoamine transporter-2 (VMAT2). The structure–activity …
binding affinity at the vesicular monoamine transporter-2 (VMAT2). The structure–activity …
N, N′-diaryl-bishydrazones in a biphenyl platform: broad spectrum antifungal agents
N,N′-Diaryl-bishydrazones of [1,1′-biphenyl]-3,4′-dicarboxaldehyde, [1,1′-biphenyl]-4,4′-dicarboxaldehyde,
and 4,4′-bisacetyl-1,1-biphenyl exhibited excellent antifungal …
and 4,4′-bisacetyl-1,1-biphenyl exhibited excellent antifungal …